BACKGROUND AND OBJECTIVE:
To enhance understanding of ethnically diverse normal newborn retinal morphology, the authors report spectral-domain optical coherence tomography (SD-OCT) macular findings in healthy Hispanic newborns.
PATIENTS AND METHODS:
In this IRB-approved prospective, observational case series, 20 full-term Hispanic newborns had dilated retinal examinations and imaging by hand-held SD-OCT without sedation at the Duke Birthing Center.
Of 20 newborns imaged (35% male; median gestational age: 39 weeks; range: 36 to 40 weeks), two (10%) had bilateral subfoveal fluid, including one case of bilateral double subretinal fluid pockets. Three eyes of two infants (10%) had retinal macular cystoid structures (one enlarged at 1.5 months, with resolution by 3 months). These SD-OCT findings were not visible by indirect ophthalmoscopy.
Some Hispanic newborns have sub-retinal fluid or macular cystoid structures on SD-OCT. This study expands our understanding of findings seen by SD-OCT in healthy full-term newborns of various races.
[Ophthalmic Surg Lasers Imaging Retina. 2013;44:448–454.]
From the Department of Ophthalmology, Kittner Eye Center, University of North Carolina, Chapel Hill, NC (MTC); University of North Carolina School of Medicine, Chapel Hill, NC (RVO); Department of Ophthalmology, Duke Eye Center, Duke University School of Medicine, Durham, NC (CAT, RSM, DT, MJA, SF, SFF); Department of Biomedical Engineering, Pratt School of Engineering, Duke University, Durham, NC (CAT, SJC, SF); Department of Pediatrics, Duke University School of Medicine, Durham, NC (GMMP, SFF); Department of Obstetrics and Gynecology, Duke University School of Medicine, Durham, NC (GKS).
Supported by the Hartwell Foundation; a grant from Research to Prevent Blindness; grant 1UL1 RR024128–01 from the National Center for Research Resources, National Institutes of Health; and the National Institutes of Health Roadmap for Medical Research. Contents are solely the responsibility of the authors and do not necessarily represent the official view of National Center for Research Resources or the National Institutes of Health.
Drs. Cabrera, Toth, Maldonado, Allingham, Farsiu, Panayotti, Swamy, and Freedman have received grant support and/or research funding. Dr. Toth receives research support from Bioptigen and could potentially receive royalties through Duke University from Bioptigen. Duke University has an equity interest in Bioptigen. Dr. Toth, Ms. Chiu, and Dr. Farsiu have patents pending on OCT image-processing techniques. The remaining authors have no financial or proprietary interest in the materials presented herein.
Address correspondence to Michelle T. Cabrera, MD, Department of Ophthalmology, University of North Carolina at Chapel Hill, 5151 Bioinformatics Building, CB 7040, Chapel Hill, NC 27599-7040; 919-843-0298; fax: 919-966-1908; email:
Received: March 18, 2013
Accepted: June 07, 2013