An accurate analysis of the thickness and volume of choroid using optical coherence tomography (OCT) requires precise visualization of the choroido-scleral interface. Results of studies that use spectral-domain OCT (SD-OCT) to look at the percent visualization of the choroido-scleral interface for accurate analysis of choroidal thickness show varying success rates. This study assessed the visualization of choroido-scleral interface in 19 healthy participants (19 eyes) prospectively recruited for consecutive high-definition raster scanning with an SD-OCT system with and without enhanced depth imaging (EDI) and a prototype long-wavelength swept-source OCT (SS-OCT) system. Choroido-scleral interface was visualized in all eyes imaged on SS-OCT, compared with 13 of 19 (68.4%) and 14 of 19 (73.6%) eyes imaged on SD-OCT without EDI (
= .009) and with EDI (
= .02), respectively. The prototype long-wavelength SS-OCT system, with its higher acquisition speed and deeper tissue penetration, may have better clinical utility in determining the involvement of choroid in various chorioretinal diseases.
Ophthalmic Surg Lasers Imaging Retina.
From the New England Eye Center, Tufts Medical Center, Boston, Massachusetts (MA, AHQ, JSD); Department of Electrical Engineering and Computer Science, Research Laboratory of Electronics, Massachusetts Institute of Technology, Cambridge, Massachusetts (JJL, IG, JGF); and Shifa College of Medicine, Islamabad, Pakistan (AHQ).
Supported in part by a Research to Prevent Blindness Unrestricted grant to the New England Eye Center/Department of Ophthalmology, Tufts University School of Medicine, and the Massachusetts Lions Club.
Dr. Fujimoto receives royalties from intellectual property owned by Massachusetts Institute of Technology and licensed to Carl Zeiss Meditec, and has stock options in Optovue. Dr. Duker receives research support from Carl Zeiss Meditec and Optovue.
The principal investigator, Dr. Duker, has full access to all the data in the study and takes responsibility for the integrity of the data and the accuracy of the data analysis.
Address correspondence to Jay S. Duker, MD, New England Eye Center, 800 Washington Street, Boston, MA 02111; email:
Received: January 28, 2013
Accepted: June 07, 2013