Ophthalmic Surgery, Lasers and Imaging Retina

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Imaging: Clinical Science 

Value of Positron Emission Tomography in Staging Ocular Adnexal Lymphomas and Evaluating Their Response to Therapy

Isis Gayed, MD; M. Farahnaz Eskandari, MD; Peter McLaughlin, MD; Barbara Pro, MD; Roxana Diba, MD; Bita Esmaeli, MD

Abstract

BACKGROUND AND OBJECTIVE

An observational case series to assess the value of positron emission tomography (PET) in staging ocular adnexal lymphomas and evaluating their response to therapy.

PATIENTS AND METHODS

The clinical records of 16 consecutive patients with ocular adnexal lymphoma for whom pretreatment and posttreatment PET scans and corresponding computed tomography (CT) and magnetic resonance imaging (MRI) scans were available were compared.

RESULTS

Pretreatment PET scans demonstrated fluorine 18-fluorodeoxyglucose (FDG) positive lesions in 15 orbits of 12 patients. In 1 patient with low-grade follicular lymphoma of the orbit, PET revealed an additional focus of lymphoma in the deltoid muscle that was missed on clinical examination and conventional radiography. All of the posttreatment PET scans showed complete resolution of FDG uptake, suggesting good response to therapy. However, posttreatment CT and MRI scans demonstrated residual masses in 3 patients.

CONCLUSIONS

PET is valuable for initial staging of ocular adnexal lymphomas and may be a good adjunct to conventional imaging in evaluation of response to therapy.

[Ophthalmic Surg Lasers Imaging 2007;38:319-325.]

AUTHORS

From the Department of Nuclear Medicine (IG); the Section of Ophthalmology (MFE, RD, BE); and the Department of Lymphoma and Myeloma (PM, BP), The University of Texas M. D. Anderson Cancer Center, Houston, Texas.

Accepted for publication January 9, 2007.

Address correspondence to Bita Esmaeli, MD, Section of Ophthalmology, M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 441, Houston, TX 77030.

Abstract

BACKGROUND AND OBJECTIVE

An observational case series to assess the value of positron emission tomography (PET) in staging ocular adnexal lymphomas and evaluating their response to therapy.

PATIENTS AND METHODS

The clinical records of 16 consecutive patients with ocular adnexal lymphoma for whom pretreatment and posttreatment PET scans and corresponding computed tomography (CT) and magnetic resonance imaging (MRI) scans were available were compared.

RESULTS

Pretreatment PET scans demonstrated fluorine 18-fluorodeoxyglucose (FDG) positive lesions in 15 orbits of 12 patients. In 1 patient with low-grade follicular lymphoma of the orbit, PET revealed an additional focus of lymphoma in the deltoid muscle that was missed on clinical examination and conventional radiography. All of the posttreatment PET scans showed complete resolution of FDG uptake, suggesting good response to therapy. However, posttreatment CT and MRI scans demonstrated residual masses in 3 patients.

CONCLUSIONS

PET is valuable for initial staging of ocular adnexal lymphomas and may be a good adjunct to conventional imaging in evaluation of response to therapy.

[Ophthalmic Surg Lasers Imaging 2007;38:319-325.]

AUTHORS

From the Department of Nuclear Medicine (IG); the Section of Ophthalmology (MFE, RD, BE); and the Department of Lymphoma and Myeloma (PM, BP), The University of Texas M. D. Anderson Cancer Center, Houston, Texas.

Accepted for publication January 9, 2007.

Address correspondence to Bita Esmaeli, MD, Section of Ophthalmology, M. D. Anderson Cancer Center, 1515 Holcombe Blvd., Unit 441, Houston, TX 77030.

10.3928/15428877-20070701-08

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