Multifocal and extended depth of focus intraocular lenses (EDOF IOLs) have the potential to both correct the distance focal point of the eye and provide one or more near focal points for the treatment of presbyopia.1 Numerous lenses have been introduced to the market worldwide, and a significant subset of them have been approved for use in the United States by the U.S. Food and Drug Administration (FDA). The aim of this study was to compare the visual and patient-reported outcomes of the pivotal FDA approval trials between lenses that are available in the United States for which outcomes have not previously been published.
Patients and Methods
This study was deemed exempt from review by the Institutional Review Board of the University of California, San Francisco, because it only used de-identified outcomes data from publicly available sources. The online database of the FDA was searched to identify the Summary of Safety and Effectiveness (SSE) documents for the multifocal and EDOF IOLs approved for use in the United States as of August 1, 2020. The SSE is the document published by the FDA that includes the outcomes data presented for approval.
The PubMed database was searched for publications that included FDA approval data that had been published in the peer-reviewed literature. Publication of the SSE data for the SN6AD12, SN6AD32, and SND1Tx3 (all by Alcon Laboratories, Inc) were identified in the peer-reviewed literature, and so these lenses were excluded from the current study.
Study design, visual acuity data, contrast sensitivity data, and patient-reported outcome data was obtained from the SSE documents. Data for the monofocal control IOLs from each study were also included. All visual acuity data presented are binocular acuity at 6 months postoperatively, with the exception of the data for the SV25T, ZKB00, and ZLB00. For the SV25T, the data were reported in the SSE as monocular corrected acuity and binocular uncorrected acuity. For the ZKB00 and ZLB00, distance-corrected near acuity was evaluated monocularly. All defocus curve data presented are monocular, using best available distance spectacle correction. Summary statistics were calculated. A two-tailed t test was used to compare visual acuities between lenses. The Fisher's exact test was used to compare proportions of patients achieving levels of visual acuity between lenses.
The SSE data for the following lenses were unavailable in the peer-reviewed literature, and thus were included in this study: SV25T (ReStor Acrysof ActiveFocus; Alcon Laboratories, Inc),2 TFNT/TFAT (PanOptix; Alcon Laboratories, Inc),3 DFT/DAT (Acrysof Vivity; Alcon Laboratories, Inc),4 ZXR/ZXT (Tecnis Symfony and Symfony Toric; Johnson & Johnson Vision),5 ZLB00 (Tecnis Multifocal +3.25; Johnson & Johnson Vision), and ZKB00 (Tecnis Multifocal +2.75; Johnson & Johnson Vision).6 The ZKB00 and ZLB00 were submitted to the FDA jointly, and are included in the same SSE. The included lenses represent several different optic designs and near focal points7 (Table A, available in the online version of this article).
Characteristics of Included Lenses
Studies evaluating the DFT/DAT, SV25T, and ZXR/ZXT were designed as multi-site randomized controlled trials with patient and evaluator masking (Table B, available in the online version of this article). Patients were allocated on a 1:1 ratio to the study lens or a monofocal control lens, with bilateral IOL implantation. Surgeons were not masked. Studies evaluating the TFNT/TFAT and ZKB00/ZLB00 were multi-center, prospective non-randomized studies with masking of the outcome evaluator. Inclusion and exclusion criteria were similar between studies. All patients in both the multifocal and monofocal control groups in all studies had planned bilateral implantation with a target for bilateral emmetropia. All studies excluded patients with corneal cylinder greater than 1.00 diopters (D), as well as patients with any significant corneal or retinal pathology, or pathology that could precipitate complex cataract surgery. The DFT/DAT study specifically excluded patients with a lens power outside of the 18.00 to 25.00 D range when targeted for emmetropia. The ZXR/ZXT and ZKB00/ZLB00 studies specifically excluded patients with a lens power outside of the 16.00 to 28.00 D range when targeted for emmetropia. The primary outcome was at 6 months postoperatively for all studies.
Trial Parameters for the Included Summary of Safety and Effectiveness Data
The comparator lens was a monofocal lens for all studies. For the ZXR/ZXT and ZKB00/ZLB00 studies, the monofocal lens was the aspheric ZCB00. For the SV25T and DFT/DAT studies, the comparator lens was the aspheric SN60WF (Alcon Laboratories, Inc). For the TFNT/TFAT study, the comparator lens was the spherical SN60AT.
Visual acuity results are provided in Table C (available in the online version of this article). Acuities are provided, when available, as both distance-corrected and uncorrected. Because residual myopia may have the result of improving uncorrected near and intermediate acuity, distance-corrected intermediate and near acuities provide a better picture of the optical range of the lens. All lenses exhibited excellent corrected distance visual acuity that was not statistically inferior to the control IOL used in each study. For all studies, a non-inferiority margin of 0.1 logMAR was used.
Visual Acuity Results
Near visual acuity was evaluated at 40 cm for all lenses in the study. Due to the effect of potential residual myopia on intermediate and near acuity, the distance-corrected measurements were used for comparison. The TFNT/TFAT had a distance-corrected near Snellen equivalent of 20/25, which was the distance-corrected near acuity of all lenses included (P < .001 for all comparisons). All studies reported superior intermediate and near acuity of the multifocal or EDOF lens to the control monofocal lens (P < .001) for all comparisons.
Intermediate acuity was evaluated at 66 cm for all lenses with the exception of the SV25T lens, which was evaluated at 53 cm. Intermediate acuity results were not evaluated for the ZKB00/ZLB00 lenses in the SSE. Compared to the DFT/DAT and the ZXR/ZXT, the TFNT/TFAT had better distance-corrected intermediate distance acuity at 66 cm (P < .003 for both comparisons). Cumulative acuity results are shown in Figure 1 for the lenses that had available data.
Percentage of patients obtaining visual acuity at each level. (A) Distance acuity is given as binocular uncorrected and (B) near acuity is given as distance-corrected. Data for the control monofocal lens from each study are presented next to the multifocal lens in the patterned boxes. The near acuity values are statistically significantly different by Fisher's exact test (P < .001 for each level of acuity), the distance acuity values were not significantly different (P > .08 for all comparisons). The DFT/DAT (Vivity), SN60WF, TFNT/TFAT (PanOptix), and SN60AT lenses are manufactured by Alcon Laboratories, Inc, and the ZXR/ZTX (Symfony), and ZKB00, ZLB00, and ZCB00 lenses are manufactured by Johnson & Johnson Vision.
The defocus curves for lenses included in this study are shown in Figure 2. All defocus curves were reported as binocular using best spectacle distance correction.
Defocus curves for the included lenses. All defocus curves are binocular, with distance correction. The DFT/DAT (Vivity), SV25T, and TFNT/TFAT (PanOptix) lenses are manufactured by Alcon Laboratories, Inc, and the ZXR/ZTX (Symfony), ZKB00, and ZLB00 lenses are manufactured by Johnson & Johnson Vision. D = diopters
Mesopic contrast sensitivity without glare is shown in Figure 3. Values shown are the mean for the TFNT/TFAT, and the median for all other lenses. Contrast sensitivity measurements were taken as binocular for the TFNT/TFAT, SV25T, and ZKB00/ZLB00 lenses, and monocular for the ZXR/ZXT and DFT/DAT lenses. Photopic contrast sensitivity was inconsistently reported, and is thus not included in this study. All measurements were taken using VectorVision charts (Vector Vision, Inc). Measurements for the SV25T, TFNT/TFAT, and DFT/DAT were taken using the CSV-1000 sine wave grating, and the ZXR/ZXT, ZKB00, and ZLB00 using the Early Treatment of Diabetic Retinopathy chart. Because most studies reported the median value and there was a significant variation in the instrument used and binocular versus monocular measurements, direct comparison is impossible. The median contrast sensitivity values for the highest spatial frequency were lower for the DFT/DAT and ZKB00 lenses.
Mesopic contrast sensitivity without glare for included multi-focal lenses. All values shown are median contrast sensitivity, with the exception of data for the TFNT/TFAT, which was reported as mean. The DFT/DAT (Vivity), SV25T, and TFNT/TFAT (PanOptix) lenses are manufactured by Alcon Laboratories, Inc, and the ZXR/ZTX (Symfony), ZLB00, and ZKB00 lenses are manufactured by Johnson & Johnson Vision.
Mesopic contrast sensitivity without glare was lower for all multifocal and EDOF IOLs than the control IOL, especially at higher spatial frequencies. The TFNT/TFAT was compared to a spherical lens (the SN60AT), whereas all others were compared to an aspheric lens. With the DFT/DAT, more patients were unable to see the reference pattern under mesopic conditions than patients receiving the control IOL (17.8%, n = 19 versus 3.4%, n = 4). The number of patients unable to see the reference pattern was not reported for other lenses.
Reported rates of spectacle independence for the multifocal and EDOF lenses ranged from 21.6% for the DFT/DAT to 85% for the ZXR (Table 1). Values for the ZXR lens are given as spectacle independence all/most of the time, whereas the other lenses have values for spectacle independence all of the time. For all lenses, with the exception of the SV25T, there was a statistically significant higher percentage of patients reporting spectacle independence with the multifocal or EDOF lens versus the control monofocal lens. There was no difference in reported rates of spectacle independence between the SV25T lens and the control monofocal lens (SN60WF).
Reported Rates of Spectacle Independence for the Included Lenses
Patient-reported outcomes are difficult to compare between lenses, given the fact that each study used a unique proprietary questionnaire. The only valid comparisons that can be drawn from these data are the comparisons between the multifocal or EDOF lens and the control monofocal lens that was used in its approval study. Data for patient-reported severity of three consistently reported visual symptom variables (glare, halos, and starbursts) are shown in Table 2. The difference in the percentage of patients reporting different moderate and severe visual symptoms were compared within studies between the study multifocal or EDOF lens and the control monofocal lens (Figure 4). Across all studies, there tended to be a higher rate of moderate and severe visual symptoms reported in patients receiving the multifocal or EDOF lens versus patients receiving the control monofocal lens.
Reported Rates of Visual Symptom Severity in the Included Studies
Patient-reported outcomes data for (A) moderate and severe glare, (B) halos, and (C) starbursts. Data reported are the difference in percentage of patients reporting each level of visual symptom between the control monofocal lens and the multifocal lens. Negative numbers indicate that more control patients reported that level of visual symptom, positive numbers indicate that more multifocal patients reported that level of visual symptom. The ZKB00/ZLB00 (Johnson & Johnson Vision) study did not report values for starbursts or for mild visual symptom severity. The DFT/DAT (Vivity), SV25T, and TFNT/TFAT (PanOptix) lenses are manufactured by Alcon Laboratories, Inc, and the ZXR/ZTX (Symfony), ZKB00, and ZLB00 lenses are manufactured by Johnson & Johnson Vision.
Few secondary interventions for patient dissatisfaction secondary to the optical properties of the lens were reported in any study (Table 3). One patient receiving the TFNT/TFAT lens and one patient receiving the ZLB00 lens underwent lens removal. One patient receiving the ZKB00 lens underwent lens repositioning for decentration. In the ZXR/ZXT group, one patient receiving the EDOF lens and one patient receiving the control monofocal ZCB00 lens expressed a desire to have the lens removed that the investigators believed was due to the optical properties of the lens, but this was not performed during the study period.
Reoperations Due to Optical Properties of Lens
Multifocal and EDOF lenses represent an increasingly popular option for the correction of presbyopia after cataract surgery. During the past several years, many new lenses have been introduced to the United States market. Unfortunately, publication of rigorous comparative data regarding these lenses has not kept pace with the rate that they have been introduced, and there is a significant amount of important data kept within the SSE documents on the FDA website.
Careful examination of the data from the pivotal approval trials for the lenses included in this study revealed several common themes. They all demonstrate non-inferior distance vision to monofocal control lenses and improved intermediate and near vision, which is comparable to previously published outcomes.7–13 Commensurate with its trifocal nature and higher add power, the TFNT/TFAT lens reported the best distance-corrected near and intermediate acuity of all lenses evaluated. Most lenses, with the exception of the SV25T (ActiveFocus) lens, also yielded a measurable increase in spectacle independence compared to a control monofocal lens. Comparison of the defocus curves revealed acuity peaks commensurate with lens design and the near focal point (or points).
These lenses all also resulted in a decrease in mesopic contrast sensitivity compared to a monofocal control lens, most notable at higher spatial frequencies, which is consistent with measurements from other multifocal lenses.14–16 Because there were different methodologies used between studies, it is difficult to directly compare contrast sensitivity measurements between studies. Interestingly, the TFNT/TFAT was compared to a spherical control lens (the SN60AT). Spherical lenses have consistently demonstrated reduced contrast sensitivity compared to aspheric lenses.17
The patient visual experience is, in many ways, the most important point of any refractive procedure. Due to the heterogeneity of the questionnaires used in these studies, direct comparisons between different multifocal or EDOF lenses are impossible. This is, unfortunately, also the state of patient-reported outcomes in the literature, with a multitude of different questionnaires impairing any comparative attempt (Alió et al1 provides an excellent summary of previously published patient-reported outcomes). However, comparisons between each multifocal or EDOF lens and the control monofocal lens that it was studied against are valid because the same questionnaire was used. These comparisons reveal that the severity of patient-reported visual symptoms tends to be greater in multifocal or EDOF lenses compared to their mono-focal controls. This difference is most notable for the TFNT/TFAT and the ZLB00. The higher effective add power for these two lenses likely plays a role in the increase in visual symptoms. Although lens explantation for visual symptoms has been reported in the literature,1 it occurred uncommonly in the studies included here (< 1%).
A full understanding of the tradeoffs between visual disturbances and acuity is a difficult task, because of the inherently personal tolerance of balance between visual phenomena and acuity. The lack of, and difficulty developing, a clear defined measure of this balance has been, perhaps, the greatest limitation in the adoption of advanced technologies for IOLs. One of the conditions of the approval for the ZXR lens was the future development of a patient-reported outcomes questionnaire for use in the evaluation of presbyopia-correcting lenses. This effort is now well underway, coordinated through the American Academy of Ophthalmology and the industry leaders in the field (F. Lum, email, August 1, 2019).5 The development of a consistent and validated way for comparing different lens technologies holds great promise to assist surgeons and navigate the available options. For now, unfortunately, it remains difficult to draw conclusions on patient-centric outcomes based on the available data.
Comparative knowledge of the near acuity focal points of the available lenses and their rates of patient-reported visual phenomena can be helpful for surgeons as they navigate the increasingly complex world of multifocal and EDOF lenses. Having an excellent grasp of the properties of the available lenses can aid in patient selection and, ultimately, improve patient outcomes.
- Alió JL, Plaza-Puche AB, Férnandez-Buenaga R, Pikkel J, Maldonado M. Multifocal intraocular lenses: an overview. Surv Ophthalmol. 2017;62(5):611–634. doi:10.1016/j.survophthal.2017.03.005 [CrossRef]
- U.S. Food and Drug Administration. Premarket Approval Application P040020/S050; Summary of Safety and Effectiveness. 2015.
- U.S. Food and Drug Administration. Premarket Approval Application P040020; Summary of Safety and Effectiveness. 2019.
- U.S. Food and Drug Administration. Premarket Approval Application P930014/S126. 2020.
- U.S. Food and Drug Administration. Premarket Approval Application P980040/S065; Summary of Safety and Effectiveness. 2016.
- U.S. Food and Drug Administration. Premarket Approval Application P080010; Summary of Safety and Effectiveness. 2009.
- Negishi K, Hayashi K, Kamiya K, et al. Survey Working Group of the Japanese Society of Cataract and Refractive Surgery. Nationwide prospective cohort study on cataract surgery with multifocal intraocular lens implantation in Japan. Am J Ophthalmol. 2019;208:133–144. doi:10.1016/j.ajo.2019.07.019 [CrossRef]
- Lane SS, Javitt JC, Nethery DA, Waycaster C. Improvements in patient-reported outcomes and visual acuity after bilateral implantation of multifocal intraocular lenses with +3.0 diopter addition: multicenter clinical trial. J Cataract Refract Surg. 2010;36(11):1887–1896. doi:10.1016/j.jcrs.2010.05.028 [CrossRef]
- Lehmann R, Modi S, Fisher B, Michna M, Snyder M. Bilateral implantation of +3.0 D multifocal toric intraocular lenses: results of a US Food and Drug Administration clinical trial. Clin Ophthalmol. 2017;11:1321–1331. doi:10.2147/OPTH.S137413 [CrossRef]
- Cochener BConcerto Study Group. Clinical outcomes of a new extended range of vision intraocular lens: International Multicenter Concerto Study. J Cataract Refract Surg. 2016;42(9):1268–1275. doi:10.1016/j.jcrs.2016.06.033 [CrossRef]
- Cochener B, Boutillier G, Lamard M, Auberger-Zagnoli C. A comparative evaluation of a new generation of diffractive trifocal and extended depth of focus intraocular lenses. J Refract Surg. 2018;34(8):507–514. doi:10.3928/1081597X-20180530-02 [CrossRef]
- Sandoval HP, Lane S, Slade S, Potvin R, Donnenfeld ED, Solomon KD. Extended depth-of-focus toric intraocular lens targeted for binocular emmetropia or slight myopia in the nondominant eye: visual and refractive clinical outcomes. J Cataract Refract Surg. 2019;45(10):1398–1403. doi:10.1016/j.jcrs.2019.05.019 [CrossRef]
- Nuijts RM, Jonker SM, Kaufer RA, et al. Bilateral implantation of +2.5 D multifocal intraocular lens and contralateral implantation of +2.5 D and +3.0 D multifocal intraocular lenses: clinical outcomes. J Cataract Refract Surg. 2016;42(2):194–202. doi:10.1016/j.jcrs.2016.02.009 [CrossRef]
- Alió JL, Kaymak H, Breyer D, Cochener B, Plaza-Puche AB. Quality of life related variables measured for three multifocal diffractive intraocular lenses: a prospective randomised clinical trial. Clin Exp Ophthalmol. 2018;46(4):380–388. doi:10.1111/ceo.13084 [CrossRef]
- Pedrotti E, Bruni E, Bonacci E, Badalamenti R, Mastropasqua R, Marchini G. Comparative analysis of the clinical outcomes with a monofocal and an extended range of vision intraocular lens. J Refract Surg. 2016;32(7):436–442. doi:10.3928/1081597X-20160428-06 [CrossRef]
- Alfonso JF, Puchades C, Fernández-Vega L, Merayo C, Montés-Micó R. Contrast sensitivity comparison between AcrySof ReSTOR and Acri.LISA aspheric intraocular lenses. J Refract Surg. 2010;26(7):471–477. doi:10.3928/1081597X-20090728-04 [CrossRef]
- Awwad ST, Warmerdam D, Bowman RW, Dwarakanathan S, Cavanagh HD, McCulley JP. Contrast sensitivity and higher order aberrations in eyes implanted with AcrySof IQ SN60WF and AcrySof SN60AT intraocular lenses. J Refract Surg. 2008;24(6):619–625. doi:10.3928/1081597X-20080601-12 [CrossRef]
Reported Rates of Spectacle Independence for the Included Lenses
|Study||Spectacle Independence (%)||P|
|Multifocal IOL||Control IOL|
|SV25T||Not provided||Not provided||Not statistically significant (value not provided)|
Reported Rates of Visual Symptom Severity in the Included Studiesa
Reoperations Due to Optical Properties of Lensa
Characteristics of Included Lenses
|Lens||Manufacturer||Design||Optical Properties||Add IOL Plane (Spectacle Plane)||Year of FDA Approval||Power Range (D)||Toric Power (Lens Plane, D)|
|ZLB00a||Tecnis Multifocal +3.25||Bifocal||Aspheric anterior, diffractive posterior||+3.25 (+2.37)||2014||+5.00 to +34.00, 0.50 D increments||Not available|
|ZKB00a||Tecnis Multifocal +2.75||Bifocal||Aspheric anterior, diffractive posterior||+2.75 (+2.01)||2014||+5.00 to +34.00, 0.50 D increments||Not available|
|ZXR/ZXTa||Tecnis Symfony/Symfony Toric||Extended depth of focus||Aspheric anterior, achromatic diffractive posterior||+1.758||2016||+5.00 to +34.00, 0.50 D increments||1.50 to 3.75, 0.75 D increments|
|DFTb/DATa||AcrySof Vivity||Extended depth of focus||“Wavefront-shaped” anterior/spherical posterior||–||2020||+15.00 to +25.00, 0.50 D increments||1.50 to 3.00, 0.75 D increments|
|SV25Tb||AcrySof IQ ReSTOR +2.50||Bifocal||Apodized aspheric diffractive anterior/spherical posterior||+2.50 (+2.00)||2015||+6.00 to +30.00, 0.50 D increments||1.50 to 3.75, 0.75 D increments|
|TFNTb/TFATa||AcrySof IQ PanOptix||Trifocal||Aspheric diffractive anterior/spherical posterior||+2.17; +3.25 (+1.65; +2.35)||2019||+6.00 to +30.00, 0.50 D increments; +31.00 to +34.00, 1.00 D increments||1.50 to 3.75, 0.75 D increments|
Trial Parameters for the Included Summary of Safety and Effectiveness Data
|Lens||Study Design||Group||No. of Patients||Female (%)||Age (y)||Preop Corneal Cylinder (D)||Loss to Follow-up (%)|
|DFT/DAT (Vivity)||RCT, subject/evaluator masked||Multifocal IOL DFT/DAT||107||55.1||68.60 ± 6.60||0.51 ± 0.26||0|
|Control IOL (SN60WF)||113||56.6||68.80 ± 7.20||0.51 ± 0.26||1.8|
|TFNT/TFAT (PanOptix)||Prospective, evaluator masked||Multifocal IOL TFNT/TFAT||129||65.9||65.80 ± 7.31||0.48 ± 0.27||1.6|
|Control IOL SN60AT||114||69.3||69.00 ± 6.46||0.54 ± 0.27||0|
|SV25T (ActiveFocus)||RCT, subject/evaluator masked||Multifocal IOL SV25T||163||61.9||–||–||6.1|
|Control IOL SN60WF||166||58.8||–||–||3.6|
|ZXR/ZXT (Symfony)||RCT, subject/evaluator masked||Multifocal IOL ZXR/ZXT||148||61.5||68.00 ± 7.50||0.51 ± 0.25||0.7|
|Control IOL ZCB00||151||57.0||67.90 ± 7.90||0.53 ± 0.22||2|
|ZKB00/ZLB00 (Tecnis)||Prospective, evaluator masked||Multifocal IOL ZKB00 +2.75||147||50.3||67.60 ± 6.90||0.51 ± 0.23||1.4|
|Multifocal IOL ZLB00 +3.25||150||67.3||67.90 ± −6.80||0.49 ± 0.25||0|
|Control IOL ZCB00||148||57.4||68.50 ± 6.90||0.54 ± 0.27||1.4|
Visual Acuity Resultsa
|DFT/DAT||−0.028 ± 0.084||20/19||0.083 ± 0.054||20/24||0.253 ± 0.118||20/36|
|SN60WF||−0.071 ± 0.086||20/17||0.196 ± 0.133||20/31||0.391 ± 0.149||20/49|
|TFNT/TFAT||−0.062 ± 0.066||20/20||−0.007 ± 0.079||20/25||0.05 ± 0.07||20/25|
|SN60AT||−0.039 ± 0.009||20/20||0.327 ± 0.011||20/40||0.529 ± 0.013||20/63|
|ZXR/ZXT||0.034 ± 0.106||20/20||0.032 ± 0.086||20/20||0.229 ± 0.114||20/32|
|ZCB00||0.013 ± 0.118||20/20||0.227 ± 0.140||20/32||0.426 ± 0.159||20/50|
|ZKB00||−0.073 ± 0.101||20/23||–||–||0.170||20/30|
|ZLB00||−0.062 ± 0.075||20/23||–||–||0.106||20/26|
|ZCB00||−0.085 ± 0.076||20/16||–||–||0.488||20/60|
|DFT/DAT||0.016 ± 0.094||20/21||0.148 ± 0.124||20/28||0.359 ± 0.152||20/46|
|SN60WF||−0.036 ± 0.094||20/18||0.312 ± 0.124||20/41||0.515 ± 0.152||20/65|
|TFNT/TFAT||−0.014 ± 0.091||20/19||0.070 ± 0.125||20/23||0.105 ± 0.136||20/25|
|SN60AT||−0.039 ± 0.096||20/18||0.327 ± 0.117||20/42||0.529 ± 0.0.138||20/68|
|SV25T||0.025 ± 0.009||20/21||0.322 ± 0.014||20/42||0.426 ± 0.014||20/53|
|SN60WF||0.03 ± 0.009||20/21||0.512 ± 0.013||20/65||0.632 ± 0.013||20/86|
|ZXR/ZXT||−0.021 ± 0.082||20/19||0.087 ± 0.114||20/24||0.241 ± 0.142||20/35|
|ZCB00||−0.040 ± 0.093||20/18||0.256 ± 0.088||20/36||0.459 ± 0.183||20/58|
|ZKB00||−0.022 ± 0.087||20/19||–||–||0.252 ± 0.143||20/36|
|ZLB00||−0.012 ± 0.085||20/19||–||–||0.179 ± 0.129||20/30|
|ZCB00||−0.036 ± 0.087||20/18||–||–||0.555 ± 0.609||20/71|
|DFT/DAT||0.035 ± 0.102||20/22||0.054 ± 0.093||20/23||0.208 ± 0.104||20/32|
|SV25T||0.01 ± 0.126||20/20||0.25 ± 0.146||20/36||0.34 ± 0.163||20/44|
|SN60WF||−0.01 ± 0.103||20/20||0.34 ± 0.17||20/44||0.46 ± 0.19||20/58|
|ZXR/ZXT||−0.045 ± 0.077||20/20||0.002 ± 0.085||20/20||0.146 ± 0.112||20/25|
|ZCB00||−0.075 ± 0.081||20/16||0.134 ± 0.0.142||20/50||0.328 ± 0.167||20/40|
|ZKB00||0.008 ± 0.101||20/20||–||–||0.135||20/27|
|ZLB00||0.016 ± 0.100||20/21||–||–||0.097||20/25|
|ZCB00||−0.005 ± 0.112||20/20||–||–||0.443||20/55|
|ZXR/ZXT||0.114 ± 0.142||20/26||0.104||20/25||0.323 ± 0.146||20/42|
|ZCB00||0.088 ± 0.149||20/24||0.342||20/44||0.544 ± 0.174||20/70|
|ZKB00||0.102 ± 0.136||20/25||–||–||0.238||20/35|
|ZLB00||0.112 ± 0.131||20/26||–||–||0.185||20/31|
|ZCB00||0.078 ± 0.134||20/24||–||–||0.568||20/74|