Journal of Pediatric Ophthalmology and Strabismus

Colobomatous Microphthalmia, Heart Disease, Hearing Loss, and Mental Retardation-A Syndrome

Helen Mintz Hittner, MD, FACS; Norma J Hirsch, MD, FAAP; Gustave M Kreh, MD; Arnold J Rudolph, MD


The primary causations of typical colobomatous syndromes appear to have their origins before fertilization and not during intrauterine development. The defective closure of the optic cleft which occurs at about the sixth week of intrauterine life is known to be under genetic influ