Prophylactic corneal collagen cross-linking in combination with high myopic LASIK yielded a lower increase in epithelial thickness than LASIK alone, a study found.
The prospective study included 139 eyes: 67 eyes underwent femtosecond laser-assisted LASIK with adjunctive corneal cross-linking, and 72 eyes underwent femtosecond laser-assisted LASIK alone.
Investigators assessed three-dimensional optical coherence tomography measurements of epithelial thickness over the center 2-mm diameter disc, mid-peripheral 5-mm rim and overall 6-mm diameter disc area.
At 6 months, in subgroups up to –7 D, there were no significant differences in epithelial thickness changes between the two groups.
Mid-peripheral epithelial thickness increased 3.79 µm in the –8 D to –9 D and 3.95 µm in the –7 D to –8 D subgroups in the combination group. In the LASIK alone group, thickness in that region increased 9.75 µm in the –8 D to –9 D subgroup and 7.14 µm in the –7 D to –8 D subgroup. Both increases in the LASIK alone group were statistically significant (P = .032 and P = .041, respectively).
Disclosure: See the study for a full list of all authors’ relevant financial disclosures.