Patients who used statins had a greater risk of cataract development than those who did not use statins, according to a large study.
The retrospective cohort study included 46,249 patients who met all study inclusion criteria; 13,626 patients were statin users and 32,623 were nonusers.
Investigators used 44 variables to create a propensity score-matched cohort comprising 6,972 pairs of users and nonusers. A secondary analysis included 6,113 statin users and 27,400 nonusers.
Cataract diagnoses were based on ICD-9 codes and the type and cause of cataract.
Statin users received the drugs for at least 90 days. Among users, 73.5% of statin prescriptions were for simvastatin, 17.4% for atorvastatin, 7% for pravastatin, 1.7% for rosuvastatin and 0.24% for fluvastatin or lovastatin.
Among the score-matched cohort, statin users had significantly greater risk of developing cataract than nonusers (P = .01). Adjusted data in the secondary analysis showed that users with no comorbidities had a markedly higher risk of developing cataract (P = .003), the authors said.
Disclosure: See the study for a full list of all authors’ relevant financial disclosures.