Nursing Continuing Education
Piperacillin-tazobactam is “particularly damaging” to human gut microbiota and its use is associated with a low abundance of potentially protective bacteria, including those that might defend against Clostridium difficile and multidrug-resistant organisms, according to findings from a study of ICU patients.
Writing in Clinical Infectious Diseases, Melinda M. Pettigrew, PhD, senior associate dean of academic affairs and professor of epidemiology at Yale School of Public Health, and colleagues said there are limited data available to clinicians on the selection of antibiotics to minimize microbiota disruptions in the human gut.
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