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Short-term sitagliptin therapy preserves beta-cell function in women with PCOS, obesity

November 22, 2017

Among women with polycystic ovary syndrome and obesity participating in a lifestyle intervention, those who were assigned the DPP-IV inhibitor sitagliptin were less likely to progress to impaired glucose tolerance and type 2 diabetes than those assigned placebo, study data show.

Mojca Jensterle, MD, PhD, of the department of endocrinology, diabetes and metabolic disease at the University Medical Centre Ljubljana in Slovenia, and colleagues evaluated women (mean age, 35 years) with PCOS and obesity (mean BMI, 36.9 kg/m2) who were metformin-intolerant and randomly assigned to a lifestyle intervention plus 100 mg daily sitagliptin (Januvia, Merck; n = 15) or lifestyle intervention alone (n = 13) for 12 weeks. Researchers sought to determine whether sitagliptin plus lifestyle intervention preserves beta-cell function.

In the Journals Plus

Joint endocrinologist-nephrologist clinic reduced diabetic kidney disease progression

November 22, 2017
Patients with type 2 diabetes and stage 3 or 4 chronic kidney disease who attended a joint endocrinologist-nephrologist diabetic kidney disease clinic were less likely…
In the Journals PlusPerspective

Despite declines in sugar-sweetened beverage intake, consumption stable among Hispanics

November 22, 2017
Sugar-sweetened beverage intake in the United States declined between 2003 and 2014 in both children and adults, but consumption rates remained steady among…
In the Journals Plus

Homemade alcoholic drink causes mass poisoning in Mozambique

November 22, 2017
On the evening of Jan. 9, 2015, 51 patients arrived at a health center in rural Mozambique with similar symptoms, including sudden weakness, abdominal pain and diarrhea…
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Original Article

Key Elements to Developing a Preceptor Program

The Journal of Continuing Education in Nursing, October 2017, Volume 48 Issue 11
With competition from so many nursing programs seeking clinical sites and numerous nurses entering the health care…
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Original Article

Using the ARCC Model to Implement the 2015 ANCC COA Criteria: A North Carolina Public Health Nursing Project

The Journal of Continuing Education in Nursing, October 2017, Volume 48 Issue 11
In July 2015, the American Nurses Credentialing Center's Commission on Accreditation released updated criteria for…
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Resource Centers

Original Article

Preceptor Knowledge on Preceptorship in an Academic Hospital in Kenya

The Journal of Continuing Education in Nursing, October 2017, Volume 48 Issue 11
Clinical preceptorship is critical for the acquisition of knowledge, skills, and attitudes in nursing care. Cardinal to…
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