Nursing Continuing Education
Paul A. Volberding, MD
Study findings showed that patients with HIV who are coinfected with HPV and Chlamydia trachomatis face a substantially increased risk for high-grade anal intraepithelial neoplasia, suggesting that C. trachomatis may enhance the oncogenic potential of HPV, researchers said.
“Anal cancer has become one of the leading causes of non-AIDS defining cancers among people living with HIV (PLWH), especially among men who have sex with men (MSM). Oncogenic strains of HPV are the major etiological agents linked to the development of high-grade anal intraepithelial neoplasia (HGAIN), the precursor lesion of anal cancer. However, other contributory factors should be implicated to explain that only a small proportion of patients infected with these high-risk HPV genotypes develop HGAIN,” Mar Masiá, MD, from the infectious diseases unit at the General Hospital of Elche and Miguel Hernández University in Alacant, Spain, told Infectious Disease News.
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