Nursing Continuing Education
Krutika Kuppalli, MD
Tafenoquine is effective for the radical cure of Plasmodium vivax malaria, and a single-dose regimen resulted in a significantly lower risk of P. vivax recurrence, according to two studies published in The New England Journal of Medicine. However, tafenoquine was not shown to be noninferior to another drug in the same class — primaquine.
Based on the results of 13 safety and efficacy studies, the FDA approved tafenoquine for the prevention of P. vivax relapse in adults and teens last summer. WHO currently recommends chloroquine or artemisinin-based combination therapy to treat P. vivax malaria and clear asexual parasites. To kill hypnozites and prevent relapse, the agency also advises treating with the 8-aminoquinoline primaquine for 14 days.
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