High recruitment and retention rates are hallmarks of scientifically rigorous longitudinal research. However, recruitment and retention are challenging, especially with older adults and minorities. In this article, we discuss strategies that have enabled us to retain more than 80% of both Black and White women in a 5-year observational study. To overcome challenges such as staff turnover and introduction of computerized record systems, we developed a time-saving handout, streamlined procedures for documenting contact information, and motivated site staff through weekly personal contact. We responded to problems with mailed privacy consent forms by garnering approval for verbal consent that allowed immediate response to participants’ questions. In addition to standard steps to minimize attrition, we encouraged ongoing participation with personal letters following interviews, “refrigerator reminders” of the next interview date, and “missing you” letters following missed appointments. We believe these and other strategies described in this article were responsible for our high retention rate.