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Glucocorticoid replacement doses tied to mortality risk in nonfunctioning pituitary adenoma

June 27, 2017

Patients with nonfunctioning pituitary adenoma who receive daily hydrocortisone replacement doses greater than 20 mg are at increased risk for death from any cause vs. similar patients receiving lower doses and those without secondary adrenal insufficiency, according to findings published in the European Journal of Endocrinology.

“The previously demonstrated excess mortality in patients with adrenal insufficiency has been mainly attributable to cardiovascular, respiratory and infectious diseases as well as cancer,” Daniel S. Olsson, MSc, MD, PhD, of the Institute of Medicine, Sahlgrenska Academy, University of Gothenburg, Sweden, and colleagues wrote. “It is likely that the degree of adrenal insufficiency is of importance for outcome and that patients who are completely insufficient may be more vulnerable to intercurrent illness, whereas patients with partial [adrenocorticotropic hormone] deficiency may be overtreated under normal unstressed conditions using conventional replacement doses. Hence, inadequate treatment of hypocortisolism remains a significant cause of death during stressful events and intercurrent illness in patients with hypopituitarism.”

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Lethal DMAC persists among patients with HIV

June 27, 2017
Despite the availability of effective ART, disseminated Mycobacterium avium complex, or DMAC, is still a mortal danger to patients with HIV/AIDS, according to…
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Grading system may predict recurrence, progression of pituitary neuroendocrine tumors

June 27, 2017
The risk for recurrence or progression of pituitary neuroendocrine tumors in adults is significantly associated with age and tumor type, according to findings published…
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Diabetes, prediabetes prevalence high in Chinese adults

June 27, 2017
The overall prevalence of diabetes among adults in China reached nearly 11%, and prevalence of prediabetes reached nearly 36% in 2013, according to nationally…
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Curriculum Revision: Student Stress and Lessons Learned

Journal of Nursing Education, June 2017, Volume 56 Issue 6
Curricular revision and engaging students in learning are important aspects of preparing students for a complex health…
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Public Stigma Toward Mental Illness in Jordan: A Cross-Sectional Survey of Family Members of Individuals With Schizophrenia, Depression, and Anxiety

Journal of Psychosocial Nursing and Mental Health Services, June 2017, Volume 55 Issue 6
Stigma affects family members of individuals with mental illness. A survey of 640 family members of individuals with…
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American Association of Nurse Practitioners National Conference

American Association of Nurse Practitioners National Conference

CNE Article

Identification and Treatment of Adolescents With Perinatal Anxiety and Depression

Journal of Psychosocial Nursing and Mental Health Services, June 2017, Volume 55 Issue 6
Perinatal mood and anxiety disorders (PMAD) are the most common, yet under-diagnosed and undertreated complication of…
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