PROMIS10 measurement responsive to patient-reported changes in lupus
The Patient-Report Outcomes Measurement Information Systems global health short form is responsive to patient-reported – but not physician-reported – changes in lupus, according to findings published in Arthritis Care & Research.
“While numerous universal and disease-specific [patient-reported outcomes(PRO)] measures are available, their use at the point of care has been limited by cost, burden of implementation, inadequate validation, and poor interpretability,” Shanthini Kasturi, MD, of Tufts Medical Center, and colleagues wrote. “The Patient-Reported Outcomes Measurement Information System global health short form (PROMIS10) has emerged as an attractive universal PRO measure because it addresses many of these limitations.”
“PROMIS10, a 10-item global PRO instrument, was developed as part of the National Institutes for Health Roadmap initiative to create a national resource for precise and efficient measurement of patient-reported symptoms, functioning and health-related quality of life across medical conditions,” they added. “PROMIS10 combines items evaluating physical health, pain, fatigue, mental health, social health, and general health to provide a snapshot of global health through physical and mental health summary scores normalized to the general population.”
To analyze the responsiveness of PROMIS10 among patients with SLE, Kasturi and colleagues conducted a prospective, longitudinal study of adults who received outpatient care at the Hospital for Special Surgery’s Lupus Center of Excellence, in New York. A total of 223 patients with SLE completed baseline PROMIS10 assessments at the first of two visits, conducted at least 1 month apart. Of those initial participants, 186 completed the second set of questionnaires. Participants also completed the Short Form-36 (SF-36) assessment.
The PROMIS10 assessment includes seven questions related to general physical, emotional and social health, as well as three questions covering emotional health, fatigue and pain over the course of the previous week. The researchers evaluated PROMIS10 responsiveness, in the physical and mental health domains, among patients who demonstrated improved or worse health status based on the SF-36.
According to the researchers, PROMIS10 demonstrated mild-to-moderate responsiveness to patient-reported improvement, and worsening, of health status for both physical and mental health domains. However, PROMIS10 performed poorly in responding to changes in physicianreported measures of disease activity.
“Our data suggest that PROMIS10 is a responsive tool for monitoring and detecting changes in global physical and mental health status related to SLE and understanding SLE patients’ longitudinal experience of disease,” Kasturi and colleagues wrote. “As a valid yet parsimonious universal instrument, PROMIS10 may be practical for use across the clinical settings SLE patients encounter, particularly as the survey continues to be implemented across health systems.” – by Jason Laday
Disclosure: The researchers report no relevant financial disclosures.