Issue: December 2018
September 18, 2018
1 min read

AWIR 2nd Annual Immunology Bootcamp Part 1: TNF and IL-6 Biology and Inhibitors

Issue: December 2018
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Chronic inflammatory diseases, such as rheumatoid arthritis, psoriasis, psoriatic arthritis, vasculitis and axial spondyloarthritis, represent a group of clinically heterogenous disorders that share a similar immunopathology. Untreated immune-mediated inflammatory diseases (IMIDs) can lead to devastating consequences. This educational activity, led by an expert rheumatologist, addresses the underlying pathogenesis of IMIDs and the utilization of TNF and IL-6 inhibitors.


1. Which of the following is not an effect of TNF in the pathogenesis of rheumatoid arthritis?

      A. Activates B-cells to produce antibodies directed against cartilage.
      B. Activates monocytes to secrete IL-1.
      C. Activates synovial fibroblasts to secrete IL-6.
      D. Activates endothelial cells to produce surface adhesion molecules.

2. For which of the following rheumatologic conditions is sarilumab approved?

      A. Psoriasis.
      B. Temporal Arteritis.
      C. Sarcoidosis.
      D. Rheumatoid Arthritis.

Click here to view this activity.

Learning Objectives:

Upon completion of this educational activity, participants should be better able to:

  • Examine the underlying pathology of chronic immune-mediated inflammatory conditions and resulting clinical implications.
  • Review the immunological targets of available and emerging immune-based therapies.
  • Select treatment for patients with IMID based on the latest clinical evidence and patient characteristics.


Author(s)/Faculty: Leonard H. Calabrese, DO; Jeffrey L. Kaine, MD; John R. P. Tesser, MD; Grace C. Wright, MD, PhD, FACR
Source: Healio Rheumatology Education Lab
Type: Lecture
Articles/Items: 5
Release Date: 10/11/2018
Expiration Date: 10/10/2019
Credit Type: ABIM MOC / CME
Number of Credits: 0.5
Cost: Free
Providers: Vindico Medical Education

CME Information

Provider Statement: This continuing medical education activity is provided by Vindico Medical Education.
Support Statement: This continuing medical education activity is provided by Vindico Medical Education.
Target Audience: The intended audience for this activity is rheumatologists and other health care professionals involved in the treatment of patients with rheumatoid arthritis (RA) and other chronic inflammatory conditions.