Lower vitamin D level linked to higher RA disease severity
Vitamin D deficiency is associated with increased disease severity among patients with rheumatoid arthritis, according to findings presented at the AACC Annual Scientific Meeting & Clinical Lab Expo, in Chicago.
“According to the results obtained, we have observed that vitamin D deficiency is associated with the activity of [RA],” Jose Luis Garcia de Veas Silva, PhD, of Hospital Universitario Campus de la Salud in Spain, a coauthor of this study, said in a press release. “Patients with active disease had lower levels of vitamin D than those with disease in remission. Our results indicate that vitamin D supplementation should be considered in the treatment of patients with RA.”
To determine the relationship between levels of 25-hydroxyvitamin D and RA disease severity, Garcia de Veas Silva and colleagues conducted a case-control study of blood samples from 78 adult patients with RA and 41 healthy controls. Participants with RA included 29 patients in remission and 49 with active disease status. The researchers analyzed disease activity using the DAS28 index, with remission defined as a DAS28 index of less than 2.6. A 25-hydroxyvitamin D level of less than 20 ng/mL was defined as vitamin D deficient.
The researchers used the Mann-Whitney test to compare quantitative variables, including 25-hydroxyvitamin D level, DAS28 index, number of painful joints, the number of inflamed joints and several biomarkers. In addition, they used the Chi-square test to compare qualitative variables, based on n contingency tables and the Spearman correlation analysis to study the correlation between variables.
According to Garcia de Veas Silva and colleagues, 25-hydroxyvitamin D levels were lower among patients with RA, compared to their healthy peers (P = .002), with just 33% of participants with RA demonstrated an adequate amount of vitamin D, defined as between 30 ng/mL and 100 ng/mL.
In addition, 31% of patients with RA were determined to be vitamin D deficient, and 36% had inadequate levels of vitamin D. Among patients with RA, 25-hydroxyvitamin D levels were lower in those with active disease status, compared to those in remission (P < .0001). The researchers also noted an inverse correlation between 25-hydroxyvitamin D levels and DAS28 index. – by Jason Laday
Garcia de Veas Silva, JL. Abstract A-385. Presented at the AACC Annual Scientific Meeting & Clinical Lab Expo; July 31 to Aug. 2, 2018; Chicago.
Disclosure: Healio Rheumatology was unable to determine Garcia de Veas Silva’s financial disclosures at the time of publication.