Poor clinical response in RA yields short-term risk for type 2 diabetes
Patients with rheumatoid arthritis who have a poor clinical response had a significant short-term risk for developing type 2 diabetes, according to results published in PLOS ONE.
Researchers collected demographic characteristics, smoking habits, RA features and complications, comorbidities and medications used among 439 patients with RA at study entry and after 12-month follow-up. Researchers categorized patients as underweight, normal weight, overweight or obese, and assessed disease activity using the DAS28.
After 12 months of prospective follow-up, results showed 7.1% of patients developed type 2 diabetes. Regression analysis showed a significant association between the presence of high blood pressure, impaired fasting glucose at first observation and poor EULAR-DAS28 response at follow-up with an increased likelihood of being classified with type 2 diabetes.
Researchers noted impaired fasting glucose among 7.7% of patients after 12-month follow-up. An increased likelihood of impaired fasting glucose was significantly associated with the presence of high blood pressure and poor EULAR-DAS28 response, according to regression analysis. – by Casey Tingle
Disclosures: The authors report no relevant financial disclosures.