April 25, 2017
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Psoriatic arthritis linked with diabetes, other endocrine disorders

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Psoriatic arthritis was linked with diabetes, Cushing disease, hypothyroidism and osteoporosis, according to a recent analysis of Israeli patients.

Using a Clalit Health Services database, Devy Zisman, MD, at Carmel Medical Center in Israel, and colleagues identified 3,161 patients who were diagnosed with psoriatic arthritis (PsA) between 2002 and 2013. Validation of diagnosis in this cohort had a positive predictive value of 90.5%. Each patient with PsA was matched by age and gender with 10 controls from the general population who did not have rheumatic disease.

Devy Zisman
Devy Zisman

After adjustment for age, gender, smoking, obesity and steroid use, investigators found an increased risk for diabetes in patients with PsA (ratio = 1.35). After adjustment for age, gender, smoking and steroid use but not obesity, they noted an increased risk for osteoporosis (ratio = 1.56) for patients with PsA. An adjustment for only age and gender, revealed an increased risk for hypothyroidism (ratio = 1.61) among patients with PsA. In addition, only osteoporosis was linked to disease-modifying antirheumatic drug use (ratio = 1.37), which indicated a more severe stage of disease. However, investigators found no increased risk for Addison disease, acromegaly, hyperthyroidism, hypoparathyroidism, hyperparathyroidism, hyperprolactinemia, diabetes insipidus or pituitary adenoma.

“Physicians should be aware of these comorbidities and screen for [diabetes mellitus] DM, hypothyroidism and osteoporosis to provide optimal medical care to their patients with PsA,” Haddad and colleagues wrote. – by Will A. Offit

Disclosure: The researchers report no relevant financial disclosures.