Higher bone mineral density associated with reduced risk for hip osteoarthritis
Higher bone mineral density was associated with a reduced risk for hip osteoarthritis, but an increased risk for knee osteoarthritis, according to data published in Arthritis Care & Research.
Kamil E. Barbour, PhD, in the arthritis program of the division of population health at the CDC, and colleagues assessed 1,474 patients from the Johnston County Osteoarthritis Project who had follow-up between 1999 and 2010 (median follow-up, 6.5 years).
The researchers used Weibull regression models to assess the association between both hip and knee osteoarthritis and hip bone mineral density, which was determined by dual-energy X-ray absorptiometry. They defined radiographic osteoarthritis (ROA) as a Kellgren-Lawrence grade of at least 2 and symptomatic ROA as the onset of both ROA and symptoms. They divided bone mineral density into quartiles: low, intermediate-low, intermediate-high and high.
The researchers found intermediate-high (hazard ratio = 0.52) and high bone mineral density (hazard ratio = 0.56) were associated with reduced risk for hip symptomatic ROA, compared with low bone mineral density. However, high bone mineral density was not associated with risk for hip ROA. In addition, intermediate-low (hazard ratio = 2.15) and intermediate-high bone mineral density (hazard ratio = 1.65) were associated with increased risk for knee sROA. – by Will Offit
Disclosure: The researchers report no relevant financial disclosures.