Mood disorders second most frequent neuropsychological event in patients with SLE
Mood disorders were the second most frequent event experienced by patients with systemic lupus erythematosus, with about one-third of the events attributable to the disease, according to recently published study results.
A prospective study of 1,827 patients with newly onset systemic lupus erythematosus (SLE) from 32 centers in 11 countries was conducted. Patients were assessed at enrollment and at follow-ups for up to 14 years (mean follow-up: 4.73 years) and clinical manifestations, type of treatments, disease activity and damage index were recorded. American College of Rheumatology (ACR) case definitions of 19 neuropsychological syndromes were used to identify nervous system events, including major depressive-like episode, mood disorder depressive features, mood disorder with manic features and mood disorder with mixed features. Measurements of lupus anticoagulant, immunoglobulin G autoantibodies to cardiolipin, beta-2-glycoprotein I, ribosomal P and NDMA glutamate receptor 2 were taken at study enrollment. Associations between a number of variables and the potential relationship between mood disorders and SLE were examined using Cox regression.
During the study period, 232 patients experienced 256 mood disorders, and 98 of the 256 events could be attributed to SLE. Major depressive-like episodes were the most common events, followed by mood disorder with depressive features. Other disorders accounted for eight events of 256, according to the researchers.
After 10 years, the estimated cumulative incidences of experiencing any mood disorder or any mood disorders attributable to SLE were 17.7% and 7.9%, respectively. A greater risk for mood disorder was seen in patients who had other neuropsychological experiences and Asians had a lower risk for mood disorder, the researchers reported. – by Shirley Pulawski
Hanly JG, et al. Paper #SAT0388. Presented at: European League Against Rheumatism Annual European Congress of Rheumatology; June 10-13, 2015; Rome.
Disclosure: The researchers report no relevant financial disclosures.