August 28, 2015
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Obstructive sleep apnea worsens symptoms, QOL in patients with PTSD

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Patients with combat-related PTSD who also had obstructive sleep apnea demonstrated worsened sleep-related symptoms and quality of life compared with patients without sleep apnea and healthy controls, according to study results.

Patients with PTSD and obstructive sleep apnea also displayed a limited adherence and response to positive airway pressure therapy, according to the researchers.

“In our population, we found that either PTSD or obstructive sleep apnea (OSA) were associated with worsened symptoms of sleepiness, fatigue and sleep-related quality of life (QoL) in comparison to normal subjects,” Christopher J. Lettieri, MD, a pulmonary and critical care medicine consultant to the U.S. Army Surgeon General, and colleagues wrote. “The presence of both OSA and PTSD lead to greater impairments than either condition alone.”

Lettieri and colleagues conducted a case-controlled observational study of active duty service members who received outpatient care for combat-related PTSD at Walter Reed Army Medical Center between 2008 and 2012 to analyze the impact OSA had on symptoms and QoL in patients with PTSD.

The analysis included 200 consecutive patients with PTSD and evaluated for OSA, 50 consecutive aged-matched patients with OSA but without PTSD and 50 aged-matched healthy controls.

Almost all (96.9%) of the patients with PTSD reported subjective sleep complaints such as daytime sleepiness and poor quality sleep.

Less than half of the patients with PTSD (41.2%) experienced reduced sleep efficiency and 31.2% of patients had prolonged sleep latency during polysomnography. Patients also had a mean total arousal index of 19.7 arousals per hour.

Patients with OSA and PTSD (n = 113) had the highest Epworth Sleepiness Scale (ESS) values compared with patients with PTSD alone (n = 87) and the healthy controls (12.5 vs. 9.5; P = .002 and 12.5 vs. 4.5; P < .001).

QoL — measured by the functional outcomes of sleep questionnaire — appeared significantly lower in patients with both PTSD and OSA (14.7) than in patients with PTSD alone (18, P = .001), OSA alone (18.7) and healthy controls (19.4, P < .001 for both).

The researchers then reassessed the patients 4 weeks after the start of positive airway pressure (PAP) therapy to evaluate adherence and response to therapy.

Patients with OSA used PAP 77.9% of nights whereas patients with both OSA and PTSD used the therapy on 53.3% of the nights (P < .001).

The patients with both disorders had a reduced treatment response to the therapy compared with patients with just OSA. ESS value dropped below 10 in 85.7% of PAP adherent and 54.5% of non-adherent patients with just OSA. However the ESS value dropped below 10 in 72.1% of adherent and 21.4% of non-adherent patients with both PTSD and OSA (P < .001).

“Although PAP can significantly improve QoL in this population, benefits are limited by poor adherence in an already compromised population,” the researchers wrote. “These results further advocate for a careful and individualized approach to therapy among patients with PTSD.” – by Ryan McDonald

Disclosure: The researchers report no relevant financial disclosures.