Disclosures: One study author reports receiving personal fees from Oxford VR outside the submitted work. The other authors report no relevant financial disclosures.
April 07, 2021
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Blended digital therapy improves paranoia in psychosis

Disclosures: One study author reports receiving personal fees from Oxford VR outside the submitted work. The other authors report no relevant financial disclosures.
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A brief blended digital therapy that targets reasoning appeared to have a beneficial effect on paranoia among individuals with psychosis, according to results of a randomized clinical trial published in JAMA Psychiatry.

The intervention, SlowMo, utilizes an interventionist-causal approach to increase the effectiveness of cognitive behavioral therapy for psychosis by targeting reasoning processes that may play a causal role in paranoia, researchers noted.

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“SlowMo builds on the encouraging findings for stand-alone and blended mobile phone apps for psychosis and, to our knowledge, is the first blended digital psychological intervention for paranoia (using digitally supported face-to-face therapy and a mobile app,” Philippa Garety, PhD, of the department of psychology at King’s College London’s Institute of Psychiatry, Psychology and Neuroscience, and colleagues wrote. “This randomized clinical trial aimed to test the efficacy of SlowMo in reducing paranoia and improving reasoning.”

The investigators analyzed primary outcome data of 332 participants who were recruited at community health services in the U.K. between May 1, 2017, and May 14, 2019. Schizophrenia-spectrum psychosis and distressing paranoia lasting 3 months or longer served as eligibility criteria. Garety and colleagues randomly assigned 181 participants to SlowMo, which consisted of eight digitally supported face-to-face sessions and a mobile app, combined with usual care and 181 to usual care only. Paranoia measured via the Green et al Paranoid Thoughts Scale (GPTS) total score at 24 weeks served as the primary outcome. GPTS total score at 2 weeks and GPTS Part A and Part B scores, the Psychotic Symptom Rating Scales, reasoning and jumping to conclusions served as secondary outcomes.

A total of 80.1% of participants in the SlowMo group completed therapy. Results showed no association between SlowMo plus usual care and greater reductions in GPTS total score at 24 weeks than usual care. Garety and colleagues observed significant effects on secondary paranoia outcomes at 12 weeks, including GPTS total score and Part A and B scores, as well as at 24 weeks, including Part B score but not Part A score. They also reported improvements in persecutory delusions according to observer ratings at 12 weeks and 24 weeks and belief flexibility at 12 weeks and 24 weeks. However, they observed no significant change in jumping to conclusions. They reported a mediating effect of improved belief flexibility and worry on paranoia change.

“Although no effect was demonstrated on the primary paranoia outcome at 24 weeks, the pattern of results on secondary outcomes indicates SlowMo had a positive effect on paranoia, mostly sustained at follow-up, that matched or exceeded effects observed for standard [cognitive behavioral therapy for psychosis] albeit delivered in fewer sessions,” the researchers wrote. “Improvements in well-being, quality of life and self-concept also occurred. The results indicate that the treatment was effective, in part, through helping people to slow down their thinking and to worry less.

“Further understanding of the mechanisms of action of SlowMo is warranted,” Garety and colleagues added. “The trial results also indicate the need for future work to enhance and translate the effects of SlowMo.”