Gabapentin enhances female sexual function
Gabapentin improved sexual function in women with provoked vulvodynia, according to findings recently published in the American Journal of Obstetrics and Gynecology.
“We performed a secondary analysis on women who were enrolled in a study of gabapentin and [provoked vulvodynia] arm for sexual function overall and also analyzed changes in sexual function based on levator muscles pain severity,” Gloria A. Bachmann, MD, MMS, of the department of obstetrics, gynecology and reproductive sciences, at Rutgers-Robert Wood Johnson Medical School, New Brunswick, New Jersey, and colleagues wrote.
They randomly assigned 89 women to receive either gabapentin or placebo.
Bachmann and colleagues found gabapentin was more effective in improving overall sexual function (adjusted mean difference, 1.3; 95% CI, 0.4-2.2) which included satisfaction (mean difference, 0.3; 95% CI, 0.04-0.5), arousal (mean difference, 0.3; 95% CI, 0.1-0.5) and desire (mean difference, 0.2; 95% CI, 0-3.3). However, sexual function stayed significantly lower compared with the 56 vulvodynia pain-free control patients and there was a moderate treatment effect among participants with baseline pelvic muscle pain severity scores above the median on the full Female Sexual Function Index (mean difference, 1.6; 95% CI, 0.3-2.8), pain domains (mean difference, 0.4; 95% CI, 0.02-0.9) and arousal (mean difference, 95% CI, 01.-0.5).
“These findings can assist the clinician in defining which patients with vulvodynia will benefit most from this intervention,” Bachmann told Healio Family Medicine.
“If the clinician and patient feel this is the best intervention after performing a benefit-risk assessment, clinicians could begin prescribing this gabapentin for painful intercourse immediately,” she added. – by Janel Miller
Disclosures: The authors report no relevant financial disclosures.