Perspective from Evan M. Loewy, MD
Disclosures: Paget reports receiving an institutional grant from the Dutch Arthritis Society and institutional nonfinancial support from Arthrex. Please see the study for all other authors’ relevant financial disclosures.
November 08, 2021
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PRP injections may not improve function or relieve symptoms in patients with ankle OA

Perspective from Evan M. Loewy, MD
Disclosures: Paget reports receiving an institutional grant from the Dutch Arthritis Society and institutional nonfinancial support from Arthrex. Please see the study for all other authors’ relevant financial disclosures.
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Compared with placebo injections, intra-articular platelet-rich plasma injections did not significantly improve function or relieve symptoms in patients with ankle osteoarthritis, according to published results.

Liam D. A. Paget, MD, of the department of orthopedic surgery at Amsterdam UMC, and colleagues randomly assigned 100 patients with ankle OA to receive two ultrasonography-guided intra-articular injections of either PRP (n=48) or saline (n=52) across six sites in the Netherlands. Researchers included patients in the study if they had tibiotalar joint space narrowing and a score of at least 40 for ankle OA pain severity on the VAS during daily activities. Researchers considered the American Orthopaedic Foot and Ankle Society score during 26 weeks of follow-up as the primary outcome.

Results showed the mean AOFAS score improved by 10 points in the PRP group and by 11 points in the saline group at 26-week follow-up compared with baseline values. Researchers found an adjusted between-group difference of –1 in 26 weeks.

Although one serious adverse event was reported in the saline group, researchers noted it was unrelated to the intervention. The PRP group had 13 other adverse events, and the saline group had eight other adverse events, according to results.