Disclosures: Okike reports receiving grants from the American Academy of Orthopaedic Surgeons.
October 13, 2021
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Hip corticosteroid injections may be associated with rapidly destructive hip disease

Disclosures: Okike reports receiving grants from the American Academy of Orthopaedic Surgeons.
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Published results showed an association between hip corticosteroid injections and rapidly destructive hip disease.

Kanu Okike, MD, MPH, and colleagues performed a case-control analysis to assess for a potential association between hip corticosteroid injection and rapidly destructive hip disease. Researchers used patients who developed rapidly destructive hip disease between 2013 and 2016 as cases and patients who underwent total hip arthroplasty for diagnoses other than rapidly destructive hip disease during the same period served as controls. Researchers considered prior intra-articular hip corticosteroid injection as the exposure of interest.

Researchers then performed a retrospective cohort analysis by analyzing data from all patients who received a fluoroscopically guided intra-articular hip corticosteroid injection from 2013 and 2016. Researchers determined the rate of rapidly destructive hip disease after injection and used logistic regression to identify risk factors for occurrence.

Kanu Okike
Kanu Okike

Results showed an association between hip corticosteroid injection with the development of rapidly destructive hip disease. Researchers found the risk of rapidly destructive hip disease increased with injection dose and the number of injections received.

In the retrospective cohort analysis, researchers noted a rate of rapidly destructive hip disease after injection of 5.4%. According to results, cases of rapidly destructive hip disease after injection were diagnosed at an average of 5.1 months following injection. Researchers also noted characteristics of rapidly destructive hip disease included rapidly progressive joint-space narrowing, osteolysis and collapse of the femoral head.

“Our research found that hip corticosteroid injections, which are commonly used to treat conditions such as osteoarthritis, can sometimes lead to rapid progression of the arthritis process — a condition known as rapidly destructive hip disease,” Okike told Healio Orthopedics. “Our findings provide information which can be used to counsel patients about the risks associated with this common procedure. In addition, caution should be taken with multiple injections and injections that are high dose.”