April 25, 2020
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Bone graft substitute for tunnel filling improved ACL reconstruction outcomes

Patients who received silicate-substituted calcium phosphate had a shorter operative time vs autologous bone graft.

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Use of silicate-substituted calcium phosphate bone substitute had equivalent knee laxity and clinical function outcomes compared with autologous bone graft 3 years after two-stage ACL reconstruction, according to published results.

Researchers randomly assigned 40 patients undergoing two-stage revision ACL reconstruction to receive either autologous iliac crest cancellous bone graft for tunnel grafting (control group; n=20) or silicate-substituted calcium phosphate in the form of sculptable microgranules (Actifuse MIS System, Baxter) as a bone graft substitute for tunnel augmentation (intervention group; n=20). Researchers assessed the patients’ functional outcomes using KT-1000 arthrometry, the Tegner score, the Lysholm score and the IKDC score after a minimum follow-up period of 2 years.

At 3.4 years, researchers followed up with 37 patients for a follow-up rate of 92.5%. Results showed no side-to-side differences in the KT-1000 measurements between the bone graft group and the silicate-substituted calcium phosphate group. Researchers noted there was a side-to-side difference greater than 5mm in 5% of patients in the silicate-substituted calcium phosphate group. From preoperative assessment to final follow-up, both groups had significant improvements and no differences in the Tegner score, Lysholm score and IKDC score, according to results.

Researchers found 22% and 11% of patients in the control and intervention group, respectively, experienced complications that required revision. However, researchers did not find any complications related to the use of silicate-substituted calcium phosphate bone substitute.

The control group had nearly double the average operative time compared with the intervention group, and the researchers noted more patients in the control group needed augmentation of the femoral tunnel, as well as additional cartilage or meniscus procedures.

“Using the bone graft substitute [silicate-substituted calcium phosphate] Si-CaP is a technically less demanding procedure than using harvested cancellous bone from the iliac crest,” the authors wrote. “The bone substitute material is applied with a syringe, similarly to bone cement, which enables precise, easy and fast filling of the tunnels.” – by Casey Tingle

 

Disclosures: Schnetzke reports he received grants from Fa. Baxter and AO Foundation. Please see the study for all other authors’ relevant financial disclosures.