March 18, 2020
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PRP-incorporated autologous bone grafting safe, effective for osteonecrosis of the femoral head

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Patients in the pre-collapse stages of post-traumatic osteonecrosis of the femoral head may receive safe and effective treatment with platelet-rich plasma-incorporated autologous granular bone grafting, according to published results.

Researchers randomly assigned 46 patients in the pre-collapse stages of post-traumatic osteonecrosis of the femoral head to be treated with either core decompression and PRP-incorporated autologous granular bone grafting (n=24; treatment group) or core decompression and autologous granular bone grafting alone (n=22; control group). Researchers evaluated radiological results with X-ray and CT scans. They also assessed clinical results with Harris hip score and VAS preoperatively and at 3, 6, 12, 24 and 36 months postoperatively.

Results showed significant improvements in Harris hip scores in both treatment and control groups. However, researchers found 91.7% of patients in the treatment group reached the minimum clinically important difference for the Harris hip score compared with 68.2% of patients in the control group. At the last follow-up, patients in the treatment group also had significantly improved Harris hip and VAS scores compared with the control group, according to results.

Researchers noted 87.5% of patients in the treatment group achieved successful clinical results vs. 59.1% of patients in the control group. Results also showed 79.2% and 50% of patients in the treatment and control groups, respectively, achieved successful radiological results. The treatment group had higher survival rates based on the requirement for further hip surgery as an endpoint vs. the control group, according to results.

https://preview.healio.com/orthopedics/biologics/news/online/{14bf0d87-3705-4858-bb90-a08c48704035}/prp-incorporated-autologous-bone-grafting-safe-effective-for-osteonecrosis-of-the-femoral-head
Of patients with post-traumatic osteonecrosis of the femoral head treated with core decompression and PRP-incorporated autologous granular bone grafting, 87.5% achieved successful clinical results vs. 59.1% of patients in a control group.

“Combining fresh autologous granular bone and PRP may provide the void filler and structural support after necrotic bone removal, which offers a chance for the PRP and fresh bone graft to combine their advantages together during the core decompression procedure,” the authors wrote. “The present study has demonstrated encouraging effects of this method and provides another choice for treatment in [Association of Research Circulation Osseous] ARCO stages II to III of post-traumatic [osteonecrosis of the femoral head] ONFH.” – by Casey Tingle

 

Disclosures: The authors report no relevant financial disclosures.