March 05, 2020
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Use of PRP in carpal tunnel syndrome may lead to earlier recovery of hand grip strength

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Patients who received platelet-rich plasma during surgical treatment of carpal tunnel syndrome regained hand grip strength earlier than patients who received placebo, according to published results.

Researchers randomly assigned 50 patients with mild to extreme carpal tunnel syndrome undergoing open surgical release of the carpal ligament to receive 3 mL of either platelet-rich plasma (n=25) or platelet-poor plasma (n=25). Researchers considered hand grip strength as the primary outcome measure, while time taken off work after surgery and Wong-Baker Faces Scale, Boston Carpal Tunnel Questionnaire and Southampton Wound Assessment Scale scores were considered secondary outcomes. Patients were evaluated preoperatively and at 6-weeks postoperatively.

Results showed improvements in pain, severity of symptoms and functional status in both groups. Although a between-group analysis for hand grip strength showed no differences between the PRP and platelet-poor plasma group at 6-week follow-up, researchers found the PRP group regained pre-surgery hand grip strength significantly earlier vs. the platelet-poor plasma group. Researchers noted no statistically significant differences for Southampton Wound Assessment Scale scores at 6-week follow-up between the two groups. No surgical complications occurred in either group at 6-week follow-up and both groups had a similar amount of leave from work after their surgery, according to results.

“Exploration of the efficacy of PRP as an adjuvant to surgical [carpal tunnel syndrome] CTS treatment merits further study, although future experiments should address the mechanism by which PRP irrigation aids the early recovery of [hand grip strength] HGS and should optimize the conditions of its use to maximize the benefits of this potential therapy,” the authors wrote. – by Casey Tingle

 

Disclosures: The authors report no relevant financial disclosures.