December 12, 2019
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Subtalar arthrodesis with adipose-derived cellular bone matrix had lower fusion rate vs autograft

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J. Chris Coetzee

Use of adipose-derived cellular bone matrix in subtalar arthrodesis augmentation had lower rates of radiographic fusion compared with autograft, according to results.

J. Chris Coetzee, MD, and colleagues randomly assigned 140 patients undergoing subtalar arthrodesis to receive adipose-derived cellular bone matrix implantation or autograft. Researchers collected standard three-view weight-bearing radiographs at 6 weeks, 3 months, 6 months, 1 year and 2 years postoperatively and CT scans at 6 months postoperatively. Fusion, defined at 45% or greater osseous bridging across the posterior facet of the subtalar joint as measured on CT scan, was considered the primary radiographic endpoint, and secondary endpoints included American Orthopaedic Foot & Ankle Society Ankle-Hindfoot Scale, foot function index-long form, SF-12, VAS pain scale, adverse events and complications.

Overall, 52 and 57 patients underwent arthrodesis with adipose-derived cellular bone matrix and autograft, respectively. Results showed 30.8% of patients in the adipose-derived cellular bone matrix group and 54.4% of patients in the autograft group achieved fusion at 6 months as measured on CT. When assessed by clinical and radiographic evaluation, 78.8% of patients in the adipose-derived cellular bone matrix group and 87.7% of patients in the autograft group achieved fusion at 6 months. Both groups had significant functional improvement from baseline in quality of life outcome measures, according to results. Researchers noted 10.5% of patients in the autograft group experienced serious adverse events vs. 23.1% of patients in the adipose-derived cellular bone matrix group.

Coetzee told Healio.com/Orthopedics, “There are a few take-home messages [to this study]: 1) The subtalar joint continues to be a complicated joint to fuse, no matter what message is used; 2) Always looking at new technology objectively before adopting it as gospel; [and] 3) Standard X-rays are of very little, if any value to determine whether the subtalar joint is fused. The only reliable imaging study is a CT scan.” – by Casey Tingle

 

Disclosures: Coetzee reports he received grants from AlloSource and other support from Integra, Paragon, Arthrex, the American Orthopaedic Foot & Ankle Society, American Academy of Orthopaedic Surgeons, Zimmer, AlloSource, Tornier, Foot and Ankle International, Biomet and Stryker. Please see the study for a list of all other authors’ relevant financial disclosures.