August 25, 2017
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Tranexamic acid yields decreased blood loss, hospital stay after THA

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Administration of tranexamic acid during total hip arthroplasty led to a decrease in blood loss and duration of inpatient stay, according to recently published results. However, the results did not show an improvement in measures of pain and mobility.

Researchers randomly assigned 101 patients undergoing total hip arthroplasty (THA) to receive either tranexamic acid or an equivalent volume of normal saline. They noted a primary outcome of thigh swelling and secondary outcomes of VAS pain score, timed up and go test, 10 meter walk test and length of stay. The researchers also recorded blood loss and the incidence of blood transfusions.

Results showed no statistically significant differences between groups regarding thigh swelling or postoperative pain or mobility. However, researchers noted patients who received tranexamic acid had a decreased length of stay of 3.58 days vs. 4.27 days for the control group. Patients who received tranexamic acid also had significantly less intraoperative blood loss as well as estimated blood loss, according to results. – by Casey Tingle

Disclosure: The researchers report no relevant financial disclosures.