Re-analysis has similar findings for corticosteroid, lidocaine vs lidocaine alone for lumbar spinal stenosis
A re-analysis using patient-prioritized items for data from a large clinical trial supported initial findings that an epidural injection of corticosteroid with lidocaine provided no significant benefits compared with injection of lidocaine alone for patients with lumbar spinal stenosis.
Researchers used the Roland-Morris Disability Questionnaire (RDQ), Sickness Impact Profile weights that were assigned to RDQ items and patient-prioritized RDQ items to re-analyze results from the Lumbar Epidural Corticosteroid Injections for Spinal Stenosis (LESS) trial. The trial included 400 patients with symptoms associated with lumbar central canal stenosis randomized to receive either an epidural injection of corticosteroid and lidocaine or an epidural injection with lidocaine alone. Investigators adjusted baseline RDQ values and findings for recruitment site to calculate differences between treatment groups and 95% confidence intervals.
Compared to baseline scores, RDQ scores improved at 6 weeks for patients in both groups. Investigators noted groups were not significantly different with regard to RDQ and patient-prioritized RDQ findings. Using the Sickness Impact Profile weights, researchers found the RDQ between-group differences were statistically significant; however, these were not considered clinically important. ‒ by Monica Jaramillo
Disclosure: Makris reports support from the Center for Translational Medicine, NIH/NCATS grants (KL2TR001103 and UL1TR001105) and the UTSW Center for Patient Centered Outcomes Research funded by AHRQ 1R24HS022418-01.