September 12, 2015
1 min read

Processed nerve allograft may lead to meaningful recovery for upper extremity nerve injury

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SEATTLE — Patients treated with a processed nerve allograft for upper extremity repairs have meaningful recovery in both sensory function and motor function, according to data presented here.

“Allograft continues to demonstrate meaningful functional recovery in sensory and mixed nerve between 5 mm and 65 mm,” Gregory M. Buncke, MD, said at the American Society for Surgery of the Hand Annual Meeting.

Buncke and colleagues used data from the RANGER processed nerve allograft (PNA; Avance Nerve Graft, AxoGen) registry for 98 patients with 102 upper extremity repairs. They compared outcome measures among patients who received PNA, nerve autograft, hollow tube conduit and healthy controls. Buncke and colleagues defined meaningful recovery as S3/M3 or better on the Medical Research Council Classification scale.

Among the patients who were treated with a PNA, the researchers observed meaningful recovery for sensory function in 85% of the repairs and in 75% of repairs for motor function. Meaningful recovery levels for patients who underwent PNA significantly differed from the hollow tube conduit group, however, the levels were not statistically different from patients who had nerve autografts. – by Christian Ingram


Buncke GM, et al. Paper #5. Presented at: American Society for Surgery of the Hand Annual Meeting; Sept. 10-12, 2015; Seattle.

Disclosure: Buncke reports he is a paid consultant for AxoGen.