July 22, 2015
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Antibiotic-loaded bone cement may not prevent deep infection after TKA

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Antibiotic-loaded bone cement did not prevent deep infection after primary total knee arthroplasty, according to study results.

Between February 2003 and October 2012, researchers reviewed 2,293 patients who underwent primary total knee arthroplasty (TKA) with 1-year follow-up. The researchers collected all potential risk factors, including age, sex, height, weight, BMI, diagnosis and operative time. During follow-up, the researchers identified 10 patients who had deep infection.

Results showed a rate of 0.40% for deep infection for both antibiotic-loaded bone cement and for plain cement, with no significant difference found with Fisher’s exact test.

After being adjusted for the unevenly distributed risk factors in both groups, logistic analysis showed no reduction in the rate of deep infection with use of antibiotic-loaded bone cement following primary TKA vs. plain cement, according to the researchers. – by Casey Tingle

Disclosure: The researchers report no relevant financial disclosures.