January 20, 2015
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OA increases risk of ischemic heart disease after TKA

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Following primary total knee arthroplasty, patients with osteoarthritis experienced a long-term risk of ischemic heart disease, according to study results.

Researchers retrospectively evaluated 3,599 patients who underwent primary total knee arthroplasty (TKA) between January 2001 and December 2008 and 14,396 matched control patients who did not. Patients were further classified by whether they had or did not have osteoarthritis (OA). The study’s principle outcome was a diagnosis of ischemic heart disease (IHD) following primary TKA or after the pseudo index date assigned to matched controls.

Results showed a significantly higher incidence rate of IHD among patients who underwent TKA vs. the control group within 1 year of follow-up. Additionally, the increase risk remained 12 months after the procedure, according to the researchers.

The risk of IHD was markedly increased in both the TKA and control groups when diagnosed with OA. Although the researchers found non-significant differences in the risk of IHD between patients with OA who underwent TKA and control patients with OA, and between control patients with OA and the control patients without OA, patients with OA who underwent TKA had a higher risk of IHD vs. control patients without OA. – by Casey Tingle

Disclosure: The authors have no relevant financial disclosures.