January 12, 2015
1 min read

Study shows PRP has no effect on patients undergoing TKA

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Use of platelet-rich plasma had no evident effect on patients undergoing total knee arthroplasty, according to study results.

Researchers randomly assigned 40 patients who were scheduled to undergo primary unilateral total knee arthroplasty (TKA) to be treated with platelet-rich plasma (PRP) or to a control group. Patients’ hemoglobin (Hb) and hematocrit levels were documented before surgery and again on days 1, 7, 14 and 28 postoperatively, and estimated blood loss was calculated. The researchers also recorded and assessed the patients’ C-reactive protein (CRP) levels, range of motion, pain levels, knee extension muscle strength, knee swelling, circumference differences, Knee Society Knee Score, Knee Society Functional Score and KOOS at various time points throughout the study.

Results showed the PRP group had a significantly longer operation time vs. the control group.  The researchers found no significant differences in Hb level reduction, CRP level or estimated blood loss after TKA between the two groups. Additionally, the use of PRP gel intraoperatively had no effect on postoperative passive range of motion, Knee Society Knee Score, Knee Society Functional Score or KOOS among patients, according to study results.

Compared with the control group, the researchers found PRP gel also did not significantly improve pain immediately after surgery. The two groups showed no significant differences in muscle strength of knee extension or in all circumferences. – by Casey Tingle

Disclosure: The authors have no relevant financial disclosures.