Researchers describe lack of homogeneity in PRP tendon studies
TORONTO — There is a need for increased consistency in how researchers report the results of tendon healing with platelet-rich plasma studies, according to a presenter here at the International Society of Arthroscopy, Knee Surgery & Orthopaedic Sports Medicine Congress.
“We’d like to see an increased reporting of such factors as type of platelet processing, white cell count and growth factors and leukocytes within the [platelet-rich plasma] PRP, ” Nikolas Baksh, BS, said.
In the study, researchers screened PubMed/Medline and EMBASE databases in June 2012 for basic science studies, including studies with controls that used PRP for tendon healing. Of 31 full-text articles that met the study inclusion criteria Baksh and colleagues established, 11 studies examined the effect of PRP on growth factor expression. Ten of the studies showed an increase in growth factor expression.
“Nine studies looked at the effects of PRP on cell proliferation and, of those, eight [studies] showed significant increases in cell proliferation with PRP treatment,” Baksh said.
He detailed the studies included in their analysis based on which ones involved histological assessments to determine the amount of collagen deposition on tendons with PRP and other factors associated with PRP use investigators determined were standard criteria for this biologic substance.
“So while PRP showed some potential beneficial effects, we thought there was a lack of homogeneity in the reporting of PRP preparation in the literature,” Baksh said. “Only 20 of the 31 studies we looked at actually reported the actual platelet concentration within the PRP.”
Baksh N. Paper #111. Presented at: The International Society of Arthroscopy, Knee Surgery & Orthopaedic Sports Medicine Congress; May 12-16, 2013; Toronto.
Disclosure: Baksh has no relevant financial disclosures.