Intense pulsed light, gland expression may reduce dry eye symptoms
Use of intense pulsed light may be beneficial in remedying the effects of dry eye disease-related meibomian gland dysfunction, according to findings published in Eye & Contact Lens.
Xiaoming Yan, MD, of the department of ophthalmology at Peking University First Hospital in China, and colleagues evaluated the efficacy of intense pulsed light (IPL) combined with meibomian gland expression (MGX) compared with instant warm compresses combined with MGX in treating dry eye disease due to meibomian gland dysfunction (MGD).
“The high and rapidly growing incidence of [dry eye disease] pushes forward the need for finding novel therapeutic approaches and more efficient management techniques of this chronic condition,” Yan and colleagues wrote.
The researchers conducted a prospective, multicenter, interventional study comprising data from 120 participants with dry eye disease due to MGD. They stratified participants into two groups; one using an IPL arm and a control arm.
Participants received treatment three times a week at 3-week intervals, Yan and colleagues wrote. The primary outcome measure was tear breakup time.
While investigators noted improved outcomes in both groups, there was a prominent improvement in the IPL arm. Further, there was a greater increase in tear breakup time in the IPL arm compared with the control arm (2.3 seconds vs. 0.5 seconds; P < .001).
Data showed reduced Standard Patient Evaluation of Eye Dryness scores in both the IPL and control arms (38% vs. 22%; P < .01). Additionally, Meibomian Gland Yielding Secretion Score improved by 197% in the IPL arm and 96% in the control arm.
Study results demonstrated reductions in corneal fluorescein staining in the IPL arm (51%) and the control arm (24%).
“Future randomized controlled trials are needed to shed more light on these issues,” Yan and colleagues wrote. “In addition, preclinical studies are need to elucidate the mechanism of action and perhaps further increase the benefits of this therapeutic approach.”