October 11, 2019
2 min read

Patients with retinal vein occlusions have increased mortality risk

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Patients with retinal vein occlusions have an increased risk of cardiovascular events and all-cause mortality, according to a study.

“Given the association of retinal microcirculatory dysfunction with systemic diseases, and the ability to noninvasively examine the retinal microvasculature, there has been significant research interest in the predictive value of RVO for incident cardiovascular events and mortality,” Chris Y. Wu, MD, and colleagues wrote.

The researchers conducted a systematic review and meta-analysis of 15 longitudinal cohort studies published in PubMed, Embase and the Cochrane Library. The targeted studies were those that evaluated association of the baseline retinal vein occlusion (RVO) that provided a multivariate-adjusted risk estimate with 95% confidence intervals with an average follow-up of at least 1 year.

The study used the Newcastle-Ottawa scale to assess the study quality. A score of 3 or less was considered poor quality, scores between 4 and 6 were considered moderate quality, and scores between 7 and 9 were considered high quality.

Results from the analysis showed that each study had a score of at least 6, indicating a moderate-to-high quality in the studies published. RVO was associated with increased risk of stroke, myocardial infarction, heart failure, peripheral arterial disease and all-cause mortality. The results of this analysis were consistent with prior meta-analysis that showed that patients with RVO had an increased 10-year risk of cardiovascular disease, but not cardiovascular mortality.

“Our results show that RVO is associated with an increased risk of all-cause mortality, but not cardiovascular mortality,” Wu and colleagues wrote. “Both analyses had substantial heterogeneity, and only two studies met inclusion criteria for the cardiovascular mortality analysis.”

The researchers concluded that more studies are required to determine the highest risk period for cardiovascular events and mortality after RVO and whether immediate evaluation, intervention or counseling will improve patient outcomes. by Erin T. Welsh

Disclosures: The authors report no relevant financial disclosures.