June 01, 2018
1 min read

AMD features that present in central retina may exist in periphery

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Ultra-widefield imaging allows clinicians to investigate the progression of peripheral abnormalities that may be associated with the development or progression of central changes, but the practice requires further investigation, according to researchers at the Association for Research and Vision in Ophthalmology meeting.

In most patients with age-related macular degeneration features in the central region, lesions in the peripheral retina were also found, raising questions as to how they might contribute to macular disease, the researchers wrote.

A total of 3,044 ultra-widefield images were available from 1,576 participants from the Northern Ireland Cohort of the Longitudinal Study of Aging.

AMD features were present in either region in 521 eyes, with 86 eyes showing features in both the central and peripheral retina.

Soft drusen were observed in both central and peripheral retina in 23 eyes but only in the central or peripheral region in 130 eyes and seven eyes, respectively.

Retinal pigment epithelial (RPE) changes in both the central and peripheral regions were found in 45 eyes and only in the peripheral region in 35 eyes, while soft drusen were found in the central region.

RPE changes were present in the central periphery in 12 eyes and in the peripheral region for 338 eyes.

The prevalence of RPE changes increased from the center (10.9%) to the periphery (73.5%), according to researchers.


Quinn NB, et al. Clinical characteristics of the peripheral retina in age-related macular degeneration in an aging population. Presented at: Association for Research in Vision and Ophthalmology; Honolulu; April 29-May 3, 2018.

Disclosures: Quinn receives financial support from Optos plc. Please see the full study for all remaining authors’ financial disclosures.