August 21, 2017
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SS-OCT effective for detecting early glaucoma

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Wide-field retinal nerve fiber layer maps using swept-source optical coherence tomography showed increased ability to detect signs of early glaucoma as compared with the conventional OCT parameters, namely circumpapillary RNFL thickness measurement and ganglion cell analysis.

In a retrospective study, 43 eyes with preperimetric glaucoma, 74 eyes with early perimetric glaucoma and 67 heathy eyes were imaged by SS-OCT using a wide-field single scan protocol. This allowed the imaging of a large, 12 x 9 mm area including the macula and optic nerve in a single scan of only 1.3 seconds. Conventional circumpapillary retinal nerve fiber layer (cpRNFL) thickness and macular ganglion cell measurement were also performed.

In some cases, wide-field RNFL thickness maps were able to detect early structural changes that were not detected with the conventional method.

As noted by the authors, the superior performance of wide-field RNFL maps is related to the higher sensitivity in visualizing the temporal margin of the RNFL defect and the ability to visualize defects apart from the optic disc. In a single scan, they provide “a wealth of information simultaneously, and the results are presented in a single, at-a-glance printout,” including wide-field RNF thickness map, SuperPixel map, clock-hour and four-quadrant cpRNFL thickness and color-coded map, ganglion cell layer with the inner plexiform layer and RNFL thickness, and color-coded map on a macular six-sector grid.

According to the authors, “this scan protocol can lower the missing rate and reduce the examination time. The examination, therefore, can be very effective, economic, time-saving and comfortable for the patients.”

They suggested using it as a complementary or alternative imaging modality to the conventional method. – by Michela Cimberle

Disclosure: The authors declare no conflict of interest.