Hydrogen peroxide solution may improve lid papillae in silicone hydrogel wearers
Patients wearing silicone hydrogel contact lenses and using Alcon’s Clear Care hydrogen peroxide solution for 3 months showed greater reductions in lid papillae and symptoms than wearers using biguanide-preserved multipurpose solution, according to Lievens and colleagues in Optometry and Vision Science.
The enrolled cohort of 131 subjects included symptomatic lens wearers with at least mild lid papillae who regularly using a biguanide-preserved multipurpose solution.
Subjects were randomized to either Clear Care or biguanide-preserved multipurpose solution (BMPS). Clear Care is a preservative-free 3% solution also containing a proprietary surfactant, Pluronic 17R4, to help with removal of deposits. The BMPS group used their habitual solution, according to the study.
Researchers graded lid papillae severity (0 to 4) in four zones of each eye at baseline and at 30, 60 and 90 days.
Using the Contact Lens Dry Eye Questionnaire (CLDEQ-8), subjects rated frequency and severity of symptoms at all time points. Researchers collected lens cases used for 1 month from the H2O2 group, and residual hydrogen peroxide concentration was analyzed at disinfection time, according to the study.
Those wearing monthly replacement lenses were given a new pair of their habitual contact lenses at baseline and at 30 and 90 days.
At baseline for the H2O2 group, mean lid papillae maximum scores were 2.3 for the right eye and 2.3 in the left eye. At baseline for BMPS the cohort, right and left eye maximum scores were 2.2.
Researchers found greater lid papillae improvement from baseline to day 90 than those randomized to BMPS.
At day 90, in the H2O2 group, mean maximum scores were 1.4 in both eyes. In BMPS users, mean maximum papillae was 1.7 in the right and 1.9 in the left.
Furthermore, at day 90, 53% of H2O2 users agreed or strongly agreed that their lenses felt like new, compared to 37% in the BPMS group.
While the Hawthorne effect may have impacted patient behavior, “means scores for severity and intensity of symptoms were uniformly statistically superior with H2O2 than with BMPS at all follow-up visits,” the researchers wrote. – by Abigail Sutton
Disclosure: This study was sponsored by Alcon Research. Lievens is an Alcon employee. For all other contributing authors please see the full study. Medical writing was funded by Alcon.