July 21, 2015
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Large fluctuation of IOP seen in patients with PE glaucoma

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Patients with pseudoexfoliation syndrome had a greater fluctuation of intraocular pressure as measured by a contact lens sensor, according to recent research published in the Journal of Glaucoma.

“High maximum IOP levels and a greater IOP fluctuation range may be contributory factors in [pseudoexfoliation syndrome] PE glaucoma,” Naoki Tojo, MD, and colleagues wrote in their study. “In this regard, treatment for glaucoma is needed not only to reduce a temporary IOP, but also to lower the peak IOP and IOP fluctuation.”

Tojo and colleagues evaluated the diurnal and nocturnal IOP levels of 22 patients using the Triggerfish (Sensimed, Lausanne, Switzerland) contact lens sensor (CLS) over a 24-hour period, according to the study. They measured corneal thickness and curvature changes before the CLS was inserted and just after it was removed.

The researchers found the mean IOP in patients with PE was 20.3 ± 3.9 mm Hg compared with 13.1 ± 2.1 mm Hg in patients with healthy eyes. Tojo and colleagues noted that IOP fluctuations over a 24-hour period were significantly larger in the PE group compared with patients with healthy eyes. Seven patients had maximum value during the nocturnal period, whereas all patients in the healthy eyes group had maximum value during the nocturnal period, according to the study.

“This larger fluctuation might be one of the reasons underlying the aggravation of the visual field by PE,” they added. – by Jeffrey Craven

Disclosure: The researchers report no relevant financial disclosures.