Association for Research in Vision and Ophthalmology
Association for Research in Vision and Ophthalmology
Source/Disclosures
Source:

Gomez Chapo M, et al. Changes in intraocular pressure after the intake of sildenafil studied in a population of healthy adults. Presented at: Association for Research in Vision and Ophthalmology annual meeting; June 12, 2020 (virtual meeting).

Disclosures: Gomez Chapo reports no relevant financial disclosures.
July 10, 2020
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Sildenafil shows IOP elevation properties

Source/Disclosures
Source:

Gomez Chapo M, et al. Changes in intraocular pressure after the intake of sildenafil studied in a population of healthy adults. Presented at: Association for Research in Vision and Ophthalmology annual meeting; June 12, 2020 (virtual meeting).

Disclosures: Gomez Chapo reports no relevant financial disclosures.
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Sildenafil, a phosphodiesterase type 5 inhibitor, could be used to treat ocular hypotension or postsurgical shallow anterior chamber, according to a presentation at the virtual Association for Research in Vision and Ophthalmology meeting.

“In previous studies, sildenafil 50 mg and 100 mg was shown to produce a substantial increase of intraocular pressure in an animal model. The purpose of the current study was to test the same drug in human volunteers with normal IOP in the city of Corrientes, Argentina,” Maria Gomez Chapo, MD, said.

Infographic detailing three study takeaways, including increase in IOP

IOP was measured with Goldmann applanation tonometry at baseline and then 1.5 hours and 4 hours later in 15 healthy subjects aged 19 to 55 years. All participants were randomly administered a dose of sildenafil 100 mg or placebo.

“Mean IOP at baseline was 16.2 mm Hg. Following administration of sildenafil, it increased 90 minutes later to 17.7 mm Hg and remained higher after 4 hours, with a little reduction of 0.3 mm Hg as compared with the previous measure,” Gomez Chapo said.

She said that the probability of obtaining these results by chance was 3%. No significant changes in IOP were recorded after ingestion of placebo.

“An increase of IOP was observed in all the cases studied, even 4 hours after the intake of the drug. Though high, the IOP did not exceed the normal IOP values, and no difference was observed in the elevation of IOP according to age,” Gomez Chapo said.

This pharmacological action can be explained by vasodilation at the level of the fenestrated capillaries of the ciliary body and may qualify the drug for future use as a treatment for ocular hypotony and shallow anterior chamber after surgery.