Association for Research in Vision and Ophthalmology
Association for Research in Vision and Ophthalmology
Source/Disclosures
Source:

Karakus S, et al. Distinct tear composition in Sjögren’s syndrome related ocular surface inflammation. Presented at: Association for Research in Vision and Ophthalmology annual meeting; June 12, 2020 (virtual meeting).

Disclosures: Karakus reports no relevant financial disclosures.
June 30, 2020
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Study investigates biomarkers of Sjögren’s syndrome-related dry eye

Source/Disclosures
Source:

Karakus S, et al. Distinct tear composition in Sjögren’s syndrome related ocular surface inflammation. Presented at: Association for Research in Vision and Ophthalmology annual meeting; June 12, 2020 (virtual meeting).

Disclosures: Karakus reports no relevant financial disclosures.
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Tear composition, specifically mucin 5AC and interleukin-8 levels, might differentiate Sjögren’s syndrome-related dry eye, according to a study presented at the virtual Association for Research in Vision and Ophthalmology meeting.

“Our aim was to investigate whether we can differentiate the inflammatory response on the ocular surface in Sjögren’s syndrome-related dry eye compared to non-Sjögren’s syndrome dry eye,” Sezen Karakus, MD, said.

Key takeaways of study infographic

In a prospective study, 21 patients with Sjögren’s syndrome (SS)-related dry eye, 20 patients with non-SS dry eye and 21 healthy subjects were enrolled. Clinical evaluation included noninvasive tear break-up time, tear osmolarity, tear sampling, Schirmer’s test and ocular surface staining. Mucins levels in tears were assessed with enzyme-linked immunosorbent assay, and cytokines were measured using Luminex assay.

“Tear [breakup time] was significantly shorter and conjunctival lissamine green staining score was significantly greater in patients with Sjögren’s syndrome. Tear mucin 5AC (MUC5AC) levels in SS-dry eye were significantly reduced,” Karakus said

A regression model showed that only conjunctival staining, among all clinical tests performed in this study, was significantly associated with reduced tear MUC5AC levels.

Among cytokines, IL-8 showed increased levels in patients with SS-related dry eye. When patients were stratified based on tear MUC5AC levels, with a cutoff value of 60 ng/mL, different patterns of cytokines were found in the two groups, and significantly increased tear IL-8 levels were detected in those with SS but not in non-SS patients.

The study demonstrated that the tear composition of SS-related dry eye differs from tear composition of non-SS dry eye.

“Specifically, low MUC5AC levels along with high IL-8 levels may be potential biomarkers for Sjögren’s syndrome diagnosis and deserve further investigation,” Karakus said.

These findings may allow for earlier diagnosis of Sjögren’s syndrome, potentially allowing earlier treatment of the most severe manifestations of the disease, such as lymphoma.