June 18, 2019
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LipiFlow more effective than warm compress for dry eye disease

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One session of vectored thermal pulsation was more efficacious than a warm compress for treating dry eye disease, according to a study.

The systematic review and meta-analysis consisted of 385 patients from four randomized controlled trials that compared the efficacy of a 12-minute vectored thermal pulsation treatment (LipiFlow, Johnson & Johnson Vision) vs. warm compress treatment. The primary outcome of the study was gland function, and secondary outcomes were tear breakup time, Schirmer test, tear osmolarity, lipid layer thickness, SPEED scores and OSDI scores.

LipiFlow patients experienced significantly greater improvement at 2 to 4 weeks in meibomian gland function, tear breakup time and SPEED scores compared with warm compress patients. There was a significantly greater reduction for LipiFlow patients in OSDI scores at 2 to 4 weeks and 3 months compared with warm compress patients.

No differences were observed between the two cohorts in Oxford staining, Schirmer tests, tear osmolarity or lipid layer thickness.

The study authors said vectored thermal pulsation has several advantages over warm compresses, “such as less time consumption (single 12-minute course) and longer treatment effects.” One trial in the study showed evidence that vectored thermal pulsation had an effect on evaporative dry eye and meibomian gland dysfunction at 1 year. – by Robert Linnehan

Disclosures: The authors report no relevant financial disclosures.