Angiogenesis, Exudation and Degeneration Meeting
Angiogenesis, Exudation and Degeneration Meeting
February 14, 2019
1 min read

Regeneron presents positive data from PANORAMA trial

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Patients in the PANORAMA trial who underwent early intervention with Eylea experienced improvements in diabetic retinopathy severity, and the majority experienced prevention of serious vision-threatening complications.

Trial investigator Charles C. Wykoff, MD, PhD, presented the 1-year results of the phase 3 trial at Bascom Palmer Eye Institute’s Angiogenesis, Exudation, and Degeneration 2019 symposium in Miami. The double-masked, randomized trial included patients with moderately severe to severe non-proliferative diabetic retinopathy (NPDR) treated with Eylea (aflibercept, Regeneron) every 16 weeks (135 participants) or every 8 weeks (134 participants) or with a sham control (133 participants).

“PANORAMA adds significantly to our understanding of how to manage NPDR without DME, as it is the first prospective trial involving high-risk NPDR eyes with moderately severe to severe NPDR since the landmark ETDRS trial of the 1980s, before we had pharmacologic treatments for DME,” Wykoff told

In a related press release, Regeneron reported that 74% of patients with severe NPDR who were treated with Eylea did not develop vision-threatening events at 1 year, whereas 53% of untreated patients did.

“Improvements in diabetic retinopathy severity achieved with aflibercept loading doses were maintained through 1 year with every 16-week re-treatments, a management approach that could realistically be achieved in the real world,” Wykoff said. – by Robert Linnehan

Disclosure: Wykoff reports he is a consultant for Alimera Sciences, Allegro, Allergan, Alnylam, Apellis, Bayer, Clearside Biomedical, DORC, EyePoint, Genentech/Roche, Kodiak, Notal Vision, Novartis, ONL Therapeutics, PolyPhotonix, Recens Medical, Regeneron, Regenxbio and Santen; is a researcher for Allergan, Apellis, Clearside Biomedical, EyePoint, Genentech/Roche, Neurotech, Novartis, Opthea, Regeneron, Regenxbio, Samsung and Santen; and is a speaker for Regeneron.