NSAIDs may inhibit prostaglandin release in femtosecond cataract surgery
Pretreatment with NSAIDs reduced prostaglandin release in patients undergoing femtosecond laser-assisted cataract surgery, according to a study.
“Therefore, it has potential to limit intraoperative laser-induced miosis,” the study authors said. “Previous studies detected elevated prostaglandin levels after femtosecond laser treatment and identified them as a potential mediator for laser-induced miosis.”
The prospective study included 75 patients who underwent image-guided femtosecond laser cataract surgery or conventional cataract surgery. Twenty patients underwent routine microincision cataract surgery (control group), 20 patients underwent routine microincision cataract surgery with a topical NSAID (control plus NSAID group), 18 patients underwent femtosecond laser cataract surgery (femtosecond laser group), and 17 patients underwent femtosecond laser cataract surgery with a topical NSAID (femtosecond laser plus NSAID group).
Prostaglandin levels obtained during surgery measured 294.4 pg/mL in the femtosecond laser group and 109.6 pg/mL in the control group; the between-group difference was statistically significant (P = .007).
NSAID pre-treatment reduced prostaglandin levels in both groups. The lowest prostaglandin concentrations were 63.9 pg/mL in the control plus NSAID group and 65.3 pg/mL in the femtosecond laser plus NSAID group.
The highest prostaglandin concentration was in the femtosecond laser group. Levels were significantly lower in the femtosecond laser plus NSAID group (P = .0009) and in the control group (P = .0007). – by Matt Hasson
Disclosure: Dick reports he is a consultant for Abbott Medical Optics. The other authors report no relevant financial disclosures.