Long-term DMEK-associated endothelial cell loss lower than in DSEK, PK
Endothelial cell loss associated with Descemet’s membrane endothelial keratoplasty compared favorably with that of Descemet’s stripping endothelial keratoplasty and penetrating keratoplasty at 5 years, according to a study.
Additionally, endothelial cell loss did not increase significantly when a single air reinjection was used with DMEK.
Researchers retrospectively analyzed data collected from 926 DMEK procedures; 673 eyes met the inclusion criteria of at least 6 months of follow-up.
The researchers recorded endothelial cell density preoperatively and at 1, 3 and 6 months, and annually for up to 5 years. Variance analysis was used to evaluate a potential association between air reinjection and endothelial cell loss.
In cross-sectional and longitudinal analyses, median endothelial cell loss was 26% at 1 month and increased to 39% at 5 years. Earlier reports showed median 5-year endothelial cell loss rates of 53% for DSEK and 70% for PK, according to the researchers.
Rates of cell loss were similar in cases with no air reinjection or one reinjection; rates were markedly higher in eyes with two or more reinjections, the researchers found (P = .017).
Disclosure: The authors have no relevant financial disclosures.