American Society of Cataract and Refractive Surgery Meeting
American Society of Cataract and Refractive Surgery Meeting
April 25, 2014
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Risk factors for infectious keratitis vary with demographics

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BOSTON — Infectious keratitis remains a significant cause of corneal morbidity and corneal blindness in Asia, although local risk factors vary with region and demographics, according to a speaker here.

“Corneal trauma is the main risk factor for developing countries. But in developed East Asian countries, it is clear that contact lens wear is the important risk factor,” Donald T.H. Tan, MD, said, giving results from the phase 1 Asia Cornea Society Infectious Keratitis Study (ACSIKS) at Cornea Day preceding the American Society of Cataract and Refractive Surgery annual meeting.

Donald T.H. Tan

The ACSIKS is a multicenter prospective observational study on infectious keratitis involving 13 major academic centers in India, China, Thailand, Japan, Korea, Taiwan, Philippines and Singapore. Since initial enrollment in April 2012, 6,569 cases of infectious keratitis have been recruited and 2,657 isolates have been archived, Tan said.

Overall, trauma was the risk factor occurring with greatest frequency, 52.7%, followed by contact lens wear in 17.7% of cases. Other risk factors for infectious keratitis were prior ocular surgery (9.5%), ocular surface disease (6.2%), topical steroids (3.1%), bullous keratopathy (1.5%), traditional medical treatments (0.8%) and other causes (8.4%).

 “Fungal and bacterial infections remain the main causes of infectious keratitis; more knowledge regarding risk factors, organisms and antimicrobial resistance patterns is needed,” Tan said.

Phase 2 of ACSIKS will incorporate study of fungal and bacterial isolates.

Disclosure: Tan is a consultant for Alcon, AllerganBausch + Lomb and Santen, sponsors of the study.