March 21, 2014
1 min read

Corneal cross-linking for infectious keratitis with corneal melt has low complication rate

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Corneal collagen cross-linking with photoactivated riboflavin for infections keratitis with corneal melting did not accelerate corneal healing but resulted in fewer complications than antimicrobial monotherapy, a study found.

The prospective study included 21 eyes of 21 patients with advanced infectious keratitis and corneal melting who underwent the photoactivated chromophore for infectious keratitis cross-linking procedure combined with anti-microbial therapy.

A control group included 19 eyes of 19 patients who underwent antimicrobial therapy alone.

Baseline logMAR corrected distance visual acuity was 2.16 in the study group and 2.01 in the control group. The difference was insignificant.

Mean time to healing was 39.76 days in the study group and 46.05 days in the control group. The difference was statistically insignificant. Corrected distance visual acuity after healing was 1.64 in the study group and 1.67 in the control group, which also was not a significant difference.

Mean ulcer size was significantly greater in the study group than in the control group (width: P = .004; length: P = .007).
Three patients in the control group had corneal perforation; one patient had recurrent infection. No serious complications were identified in the study group.

Disclosure: Hafezi is a co-inventor of the ultraviolet light source.