December 30, 2013
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Study suggests correlation between reticular pseudodrusen, geographic atrophy

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The recognition of reticular pseudodrusen on autofluorescence imaging in patients with geographic atrophy suggests a strong spatiotemporal relationship between the two, according to a study.

One hundred and twenty-six eyes of 92 patients with geographic atrophy in at least one eye that underwent sequential fundus autofluorescence (FAF) and/or near infrared reflectance (NIR-R) imaging were included in the retrospective study. Patients were followed for an average 20.4 months.

Reticular pseudodrusen were present in 93.6% of eyes and the average area of geographic atrophy was 2.8 mm2.

Researchers reported that patients in the lower 50th percentile of the primary area of geographic atrophy had a lower progression rate than those in the upper 50th percentile, which was statistically significant (P <.001). Fields with reticular pseudodrusen frequently had more progression in geographic atrophy than in those without reticular pseudodrusen, which was also statistically significant (74.2% vs. 41.7%, P < .001).

“The strong relationship between GA and RPD shown herein suggests a similar etiology; therefore understanding the pathophysiology of RPD could be crucial to understanding and treating GA,” the researchers wrote.

Disclosure: K. Bailey Freund, MD, is a consultant for Genentech, Inc. and Regeneron Pharmaceuticals, Inc.