Perspective from A. John Kanellopoulos, MD
Source: Cornea. 2014;33(1):43-48.
December 23, 2013
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Cross-linking improves visual acuity, reduces higher-order aberrations at 2 years

Perspective from A. John Kanellopoulos, MD
Source: Cornea. 2014;33(1):43-48.
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Collagen cross-linking provided good long-term visual, refractive and topographic outcomes in eyes treated for progressive keratoconus, a study found.

The prospective case series included 42 eyes of 32 patients with progressive keratoconus and a mean age of 22.4 years. Bilateral surgery was performed on 11 patients. The mean interval between diagnosis and treatment was 2.2 years.

Uncorrected and corrected distance visual acuity, refraction, topography and corneal aberrations were evaluated at baseline and 6, 12 and 24 months after surgery.

Uncorrected distance visual acuity, corrected distance visual acuity and spherical equivalent improved significantly 2 years after treatment (P < .001, P < .001 and P = .048, respectively).

Apical keratometry, differential keratometry and central keratometry decreased significantly from baseline (P < .001, P = .031 and P = .003, respectively).

Coma, trefoil, secondary astigmatism, quatrefoil, secondary coma and secondary trefoil also decreased significantly (P = .016, P = .018, P < .001, P = .031, P < 001, P = .001, respectively).

There was no significant correlation between changes in corneal higher-order aberrations and improvements to visual acuity. Only the reduction in apical keratometry correlated with improvement in corrected distance visual acuity.

Disclosure: The study authors have no relevant financial disclosures.