DSEK may be option in children with congenital hereditary endothelial dystrophy
Descemet’s stripping endothelial keratoplasty can be an alternative to penetrating keratoplasty in children with congenital hereditary endothelial dystrophy, offering early visual stabilization and a low risk of complications.
In the retrospective, comparative, interventional study, five patients had a mean age of 6.6 years and underwent PK in one eye and DSEK in the fellow eye.
All grafts were clear at 1 year, and no significant difference in the spherical component of refraction was reported; however, eyes that underwent DSEK had a significantly lower rate of astigmatism.
All eyes had improved visual acuity.
By 6 weeks, refractive error was stabilized in most DSEK eyes, while refractive error continued to change in PK eyes for almost 1 year.
Graft dislocation occurred in two DSEK cases that were treated with re-bubbling, while graft dehiscence occurred in one PK case, which was treated with re-suturing.
DSEK offers lower levels of refractive astigmatism and lower risk of allograft rejection and long-term use of corticosteroids, while avoiding the risk of suture-related infections, the study authors said.
Disclosure: The study was funded by Hyderabad Eye Research Foundation, Hyderabad, India.